Dysregulation of 1-carbon metabolism and muscle atrophy: potential roles of forkhead box O proteins and PPAR γ co-activator-1α.

Dysregulation of 1-carbon metabolism and muscle atrophy: potential roles of forkhead box O proteins and PPARγ co-activator-1α. Can J Physiol Pharmacol. 2019 Jul 03;: Authors: Laha A, Singh M, George AK, Homme RP, Tyagi SC Abstract Homocysteine, a non-proteinogenic amino acid but an important metabolic intermediate is generated as an integral component for the "1-carbon metabolism" during normal physiology. It is catabolized to cysteine via the transulfuration pathway resulting in the generation of hydrogen sulfide, a naturally endogenous byproduct. Genetics or metabolic derangement can alter homocysteine concentration leading to hyperhomocysteinemia, a physiologically unfavorable condition that causes serious medical conditions including muscle wasting. Hyperhomocysteinemia environment can derail physiological processes by targeting biomolecules such as Akt however not much is known about regarding the effects of hyperhomocysteinemia on regulation of transcription factors such as forkhead box O proteins. Recently, hydrogen sulfide has been shown to be highly effective in alleviating the effects of HHcy by serving as an anti-apoptotic factor but role of FOXO and its interaction with hydrogen sulfide are yet to be established. In this review we discuss role(s) of HHcy in skeletal muscle atrophy and how HHcy interact with FOXO and peroxisome proliferator-activated receptor gamma coactivator 1-alpha expressions that are relevant in ske...
Source: Canadian Journal of Physiology and Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Can J Physiol Pharmacol Source Type: research