Clinical phenotype and genetic risk factors for bipolar disorder with binge eating: an update.

Clinical phenotype and genetic risk factors for bipolar disorder with binge eating: an update. Expert Rev Neurother. 2019 Jul 04;: Authors: Cuellar-Barboza AB, Winham SJ, Biernacka JM, Frye MA, McElroy SL Abstract INTRODUCTION: The clinical and genetic study of psychiatric conditions has underscored the co-occurrence of complex phenotypes and the need to refine them in entities that are more precise. Bipolar Disorder (BD) and Binge Eating (BE) behavior are common psychiatric conditions that have high heritability and high co-occurrence, such that at least one quarter of BD patients have BE (BD + BE). On the other hand, genetic studies of BD alone and of BE alone suggest complex polygenic risk models, with many genetic risk loci yet to be identified. Areas covered: In this review, the authors describe studies of the epidemiology of BD+BE, its clinical features (cognitive traits, psychiatric comorbidity, and the role of obesity), genomic studies (of BD alone, eating disorders (ED) defined by BE, and BD + BE), and the therapeutic implications of BD + BE. Expert opinion: Subphenotyping of complex psychiatric disorders reduces heterogeneity and increases statistical power and effect size; thus, it enhances our capacity to find missing genetic (and other) risk factors. BD + BE shows a complex and severe clinical picture. Moreover, exploring BD + BE in genetic studies suggests a distinct genetic architecture. Differential therapeutic interventions may be needed for patie...
Source: Expert Review of Neurotherapeutics - Category: Neurology Tags: Expert Rev Neurother Source Type: research

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AbstractPurpose of ReviewBipolar disorder (BD) is a severe, common, and chronic affective disorder. This review highlights the BD and obesity connection and the role of treatments for obesity in this population.Recent FindingsPatients with BD are at a significantly increased risk for obesity, as compared to those without BD, with obesity serving as a proxy for severity and predictor of poorer outcome. BD is characterized by substantial medical burden, with obesity-related conditions contributing to premature mortality. Pharmacotherapy for BD can cause weight gain and may be moderated by binge eating behavior. Bariatric sur...
Source: Current Obesity Reports - Category: Eating Disorders & Weight Management Source Type: research
We describe the effects of LDX (50mg and 70mg) on the Sheehan Disability Scale (SDS; exploratory endpoint) from both studies. Design: The SDS was assessed at baseline, Week 6, and Week 12/early termination. Analyses included mixed-effects models for repeated measures for the examination of SDS total and domain score changes and a generalized estimating equation model to assess dichotomized remission status (remission [total score ?6] versus nonremission [total score>6]). Results: Least squares (95% confidence interval [CI]) mean treatment differences for SDS total score change from baseline at Week 12 were -2.80 (-3.98,...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Current Issue Drug Development Original Research binge eating disorder disability functionality lisdexamfetamine dimesylate Sheehan Disability Scale Source Type: research
Conclusion: Phentermine–topiramate could be helpful for weight loss and reduction of binge-eating symptoms in patients with obesity or overweight in addition to BED. Controlled studies are warranted. Binge-eating disorder (BED), an eating disorder recognized in the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5), is characterized by recurrent and distressing episodes of binge eating (eating an unusually large amount of food with a sense of loss of control over eating) without inappropriate compensatory weight-loss behaviors.1 Known as the most common eating disorder, BED is strongly assoc...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Current Issue Drug Development Original Research binge eating obesity phentermine–topiramate Qsymia® weight loss Source Type: research
Conclusion. The audio-digital recording method provides a useful second opinion that can affirm the need for a different treatment intervention in these anxious patients. A second live assessment would have required additional clinic time and added patient burden. The audio-digital recording method is less burdensome than live second opinion assessments and might have utility in both research and clinical practice settings. Keywords: Generalized anxiety disorder (GAD), anxiolytic medications, anxious symptoms, audio-digital recording, dual review, second opinions Anxiety symptoms are prevalent in most populations wher...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Current Issue Original Research anxiolytic medications anxious symptoms audio-digital recording dual review Generalized anxiety disorder (GAD) second opinions Source Type: research
In this episode of the Psych Central Show, hosts Gabe Howard and Vincent M. Wales discuss Binge Eating Disorder. At his heaviest, Gabe weighed 550 pounds. He describes in detail how he went from a “normal-sized” guy to being morbidly obese, his return to being “normal-sized,” and addresses the question of whether he was, in fact, addicted to food. During the second half of the show, our hosts welcome Lisa, a woman who was with Gabe during this period of his life. She shares her experience of what it was like being with someone with binge eating disorder and how he finally confronted it. * Sho...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Binge Eating General The Psych Central Show Source Type: blogs
Bipolar disorder ’s (BD) genetic architecture may be modified by interrelated heritable traits. For example adiposity-related traits, binge eating behavior (BE) and obesity, are positively associated with BD and compose complex subphenotypes of distinctive morbidity. We sought to perform genome wide analyses (GWA) of BD accounting for BE, body mass index (BMI) and BMI-gene interactions.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: SYMPOSIUM Source Type: research
Bipolar disorder ’s (BD) genetic architecture may be modified by interrelated heritable traits. For example adiposity-related traits, binge eating behavior (BE) and obesity, are positively associated with BD and compose complex subphenotypes of distinctive morbidity. We sought to perform genome wide analyses (GWA) of BD accounting for BE, body mass index (BMI) and BMI-gene interactions.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: SYMPOSIUM Source Type: research
Weight gain is one of the main reasons that people diagnosed with depression and other mood disorders stop taking their medication. Some people gain as much as seven percent of their body weight — or more — from psychiatric meds. In a study funded by the National Institute of Mental Health that was published in July 2006 in the Archives of General Psychiatry, researchers reported that nearly one in four cases of obesity is associated with a mood or anxiety disorder. But following a strict treatment plan that involves meds doesn’t have to mean shopping for a larger pants ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Addiction Antidepressant Antipsychotic Binge Eating Bipolar Depression Eating Disorders Exercise & Fitness Health-related Medications Research Bingeing Diet Food Addiction Junk Food Mindfulness Nutrition Obesity self-so Source Type: blogs
Conclusions: Zonisamide may have some utility, especially as an adjunctive therapy, for the management of acute phases and weight gain in bipolar disorder and for prevention of alcohol misuse. Preliminary evidence indicates zonisamide as a candidate compound for the treatment of BED and obesity. However, open-label design and small sample sizes of most available studies prevent from drawing sound conclusions about the utility of this compound in psychiatry.
Source: Clinical Neuropharmacology - Category: Neurology Tags: Review Articles Source Type: research
Obesity is not a mental disorder, yet DSM-5 recognizes a strong association between obesity and psychiatric syndromes. Disorders within the Bipolar Spectrum (BSD) and Binge Eating Disorder (BED) are the most frequent psychiatric disorders among obese patients. The aim of this research is to investigate the psychopathological differences and the distinctive eating behaviors that accompany these comorbidities in obese patients.
Source: Journal of Affective Disorders - Category: Neurology Authors: Source Type: research
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