Biological Dynamics Wants to Shake up Diagnostics with Verita

Biological Dynamics is fighting to take its diagnostic platform to the next level. And the San Diego-based company said it recently received a grant from the Bill &Melinda Gates Foundation, to help it in its mission. This marks the second time Biological Dynamics has received funding from the philanthropic organization. The first time occurred in November of 2018, according to a release on Biological Dynamics’ website. The company did not go into details regarding the grant’s sum. Biological Dynamics is developing Verita, an isolation platform. It enables the isolation of circulating biomarkers such as cell-free DNA and exosomes from whole blood, serum, and plasma without the need to pre-process samples. The company is currently applying the isolation capabilities of Verita to develop the next generation of lab and point-of-care tests for the early detection and treatment response monitoring of cancer. It is also developing a point-of-care diagnostic for the detection of tuberculosis (TB). “We’re extremely grateful to the Gates foundation especially seeing the technology and helping support us build it,” Raj Krishnan, PhD, CEO of Biological Dynamics, told MD+DI. “The first grant was used to help build a proof-of-concept diagnostic around TB. But this second grant is specifically toward building a platform technology on a smartphone interface system. Down the line, a...
Source: MDDI - Category: Medical Devices Authors: Tags: IVD Source Type: news

Related Links:

Conclusion: Several health maintenance aspects are inadequately addressed by GIs and PCPs, in part because of conflicting perceptions of responsibility. Clear guidelines and better GI/PCP communication are required to ensure effective health maintenance for patients with IBD. PMID: 31528131 [PubMed]
Source: Ochsner Journal - Category: General Medicine Tags: Ochsner J Source Type: research
AbstractThe main effectors in tumor control are the class I MHC molecule-restricted CD8+ cytotoxic T lymphocytes (CTLs). Tumor-specific CTL induction can be regulated by dendritic cells (DCs) expressing both tumor-derived epitopes and co-stimulatory molecules. Immunosuppressive tolerogenic DCs, having down-regulated co-stimulatory molecules, are seen within the tumor mass and can suppress tumor-specific CTL induction. The tolerogenic DCs expressing down-regulated XCR1+CD141+ appear to be induced by tumor-derived soluble factors or dexamethasone, while the immunogenic DCs usually express XCR1+CD141+ molecules with a cross-p...
Source: Cancer Immunology, Immunotherapy - Category: Cancer & Oncology Source Type: research
CONCLUSION: Atypical infections of the larynx may be localized and mimic laryngeal cancer on endoscopy. Tissue examination as well as microbiologic samples are diagnostic and complementary. PMID: 31522522 [PubMed - as supplied by publisher]
Source: The Annals of Otology, Rhinology, and Laryngology - Category: ENT & OMF Authors: Tags: Ann Otol Rhinol Laryngol Source Type: research
Abstract Benzocaine has been well-known for its role as anesthetic agent and largely used in oral ulcers, ear pain and dental complications. Along with lidocaine and other local anesthetics, benzocaine has marked its part as an anesthetic in surgical procedures and as Na+ channels blocker, as well. Analogues of benzocaine have been found to possess biological potentials including antibacterial antifungal and anti-cancer. Some derivatives were found to have conspicuous action against tuberculosis. Current review focuses to explore the century long potential of the molecule and its analogs that have appeared in the ...
Source: Mini Reviews in Medicinal Chemistry - Category: Chemistry Authors: Tags: Mini Rev Med Chem Source Type: research
Abstract Many deadly infections are produced by microorganisms capable of sustained survival in macrophages. This reduces exposure to chemotherapy, prevents immune detection, and is akin to criminals hiding in police stations. Therefore, the use of glyco-nanoparticles (GNPs) as carriers of therapeutic agents is a burgeoning field. Such an approach can enhance the penetration of drugs into macrophages with specific carbohydrate targeting molecules on the nanocarrier to interact with macrophage lectins. Carbohydrates are natural biological molecules and the key constituents in a large variety of biological events su...
Source: Advanced Drug Delivery Reviews - Category: Drugs & Pharmacology Authors: Tags: Adv Drug Deliv Rev Source Type: research
Conditions:   Tuberculosis, Pulmonary;   Non-Tuberculous Mycobacterial Pneumonia;   Lung Cancer;   Hemoptysis Intervention:   Sponsor:   Gachon University Gil Medical Center Completed
Source: - Category: Research Source Type: clinical trials
AbstractImmune checkpoint inhibitors (ICBs) have revolutionized cancer treatment producing remarkable and durable responses for a range of malignancies. However, the additional modulation of immune response by ICBs may rarely cause immune-related infectious complications, including re-activation of latent tuberculosis infection (LTBC) with detrimental effects on those patients ’ outcome. Here, we present two “real-world” melanoma cases that were treated in our department with blockade of PD-1/PD-L1 and developed activeMycobacterium tuberculosis (MTB) during immunotherapy. In view of these cases, we review...
Source: Journal for Immunotherapy of Cancer - Category: Cancer & Oncology Source Type: research
CONCLUSIONS:  The transcervical approach is a very suitable maneuver in selected patients with a bronchial stump at least 1 cm long, ideally 1.5 cm. PMID: 31476773 [PubMed - as supplied by publisher]
Source: The Thoracic and Cardiovascular Surgeon - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Thorac Cardiovasc Surg Source Type: research
Conclusions The transcervical approach is a very suitable maneuver in selected patients with a bronchial stump at least 1 cm long, ideally 1.5 cm. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: The Thoracic and Cardiovascular Surgeon - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Original Thoracic Source Type: research
More News: Cancer | Cancer & Oncology | Funding | Grants | Medical Devices | Molecular Biology | Tuberculosis | Websites