Towards a novel small animal proton irradiation platform: the SIRMIO project.

Towards a novel small animal proton irradiation platform: the SIRMIO project. Acta Oncol. 2019 Jul 04;:1-6 Authors: Parodi K, Assmann W, Belka C, Bortfeldt J, Clevert DA, Dedes G, Kalunga R, Kundel S, Kurichiyanil N, Lämmer P, Lascaud J, Lauber K, Lovatti G, Meyer S, Nitta M, Pinto M, Safari MJ, Schnürle K, Schreiber J, Thirolf PG, Wieser HP, Würl M Abstract Background: Precision small animal radiotherapy research is a young emerging field aiming to provide new experimental insights into tumor and normal tissue models in different microenvironments, to unravel complex mechanisms of radiation damage in target and non-target tissues and assess efficacy of novel therapeutic strategies. For photon therapy, modern small animal radiotherapy research platforms have been developed over the last years and are meanwhile commercially available. Conversely, for proton therapy, which holds potential for an even superior outcome than photon therapy, no commercial system exists yet. Material and methods: The project SIRMIO (Small Animal Proton Irradiator for Research in Molecular Image-guided Radiation-Oncology) aims at realizing and demonstrating an innovative portable prototype system for precision image-guided small animal proton irradiation, suitable for installation at existing clinical treatment facilities. The proposed design combines precise dose application with in situ multi-modal anatomical image guidance and in vivo verification of t...
Source: Acta Oncologica - Category: Cancer & Oncology Authors: Tags: Acta Oncol Source Type: research