Intensity modulated proton therapy plan generation in under ten seconds.

Intensity modulated proton therapy plan generation in under ten seconds. Acta Oncol. 2019 Jul 04;:1-5 Authors: Matter M, Nenoff L, Meier G, Weber DC, Lomax AJ, Albertini F Abstract Background: Treatment planning for intensity modulated proton therapy (IMPT) can be significantly improved by reducing the time for plan calculation, facilitating efficient sampling of the large solution space characteristic of IMPT treatments. Additionally, fast plan generation is a key for online adaptive treatments, where the adapted plan needs to be ideally available in a few seconds. However, plan generation is a computationally demanding task and, although dose restoration methods for adaptive therapy have been proposed, computation times remain problematic. Material and methods: IMPT plan generation times were reduced by the development of dedicated graphical processing unit (GPU) kernels for our in-house, clinically validated, dose and optimization algorithms. The kernels were implemented into a coherent system, which performed all steps required for a complete treatment plan generation. Results: Using a single GPU, our fast implementation was able to generate a complete new treatment plan in 5-10 sec for typical IMPT cases, and in under 25 sec for plans to very large volumes such as for cranio-spinal axis irradiations. Although these times did not include the manual input of optimization parameters or a final clinical dose calculation, they included all ...
Source: Acta Oncologica - Category: Cancer & Oncology Authors: Tags: Acta Oncol Source Type: research

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Proton therapy has an important role in the management of head and neck cancer, where the dosimetric characteristics of proton particles are advantageous for treating tumors in complex anatomic areas. In addition to highly targeted dose depositions owing to the Bragg peak and superior lateral dose distribution of proton therapy, the introduction of spot-scanning techniques that allow intensity-modulated proton therapy (IMPT) further improve dose distributions and normal-tissue sparing relative to intensity-modulated (photon) radiation therapy (IMRT), a finding that has been validated in case-matched analyses showing lower ...
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research
Technical advances have made it possible to create highly conformal dose distributions using photon-based radiotherapy, prompting interest in hypofractionated radiotherapy. Prostate cancer shows higher fractionation sensitivity and a lower α/β ratio than healthy tissue; thus, the rationale is to use higher doses per fraction compared with conventional fractionation [1–3]. Randomized studies have shown that moderate hypofractionation was not inferior to conventional fractions [4–6], but they have not demonstrated the concept of b iological dose escalation i.e.
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research
To identify biological factors that may yield a therapeutic advantage of proton therapy versus photon therapy. Specifically, the role of non-homologous end-joining (NHEJ) and homologous recombination (HR) in the survival of cells in response to clinical photon and proton beams.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Source Type: research
Removable dentures got stuck in a 72-year-old man's throat during surgery to...Read more on AuntMinnie.comRelated Reading: 3-month PET/CT helps track oropharyngeal cancer CBCT outstrips growth in all other dental x-ray segments US-guided core biopsy best for salivary gland tumors Intraoperative CT fine-tunes maxillofacial surgery Proton therapy helps oropharyngeal patients
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
/Objective(s): The standard of care of childhood parameningeal rhabdomyosarcoma (pRMS) is chemotherapy and local radiotherapy. Protons are increasingly being used in order to decrease late effects. The aim of the present study is to analyse the pattern of relapse and the correlation with dosimetric factors in pRMS treated with proton therapy (PT).
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Source Type: research
The University of Texas M.D. Anderson Cancer Center is investing $159 million into an expansion project. M.D. Anderson will more than double the size of its Proton Therapy Center at 1840 Old Spanish Trail. The expansion will grow the center’s footprint to over 160,000 square feet, enough room for the cancer center to house eight proton therapy radiation machines developed by Japanese technology man ufacturer Hitachi, according to an Aug. 8 press release. The center currently spans 73,500 square…
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
In conclusion, several influences on harmonization were identified: adherence/interpretation to/of the protocol, available technology, experience in treatment planning and use of different beam arrangements. In future, all OARs that should be included in the optimization need to be specified in order to further harmonize treatment planning. PMID: 31393203 [PubMed - as supplied by publisher]
Source: Acta Oncologica - Category: Cancer & Oncology Authors: Tags: Acta Oncol Source Type: research
Radiotherapy positioning technology developer Qfix said that it has validated...Read more on AuntMinnie.comRelated Reading: Mevion, RaySearch extend partnership Qfix validates couch top on Varian radiotherapy systems Mevion takes order from China Mevion lands Mo. order for proton therapy system Qfix debuts new thermoplastic masks at ASTRO 2018 Qfix readies product launches for ASTRO 2014
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Purpose of review To discuss alternative strategies for multimodal treatments of nonmetastatic bladder–prostate rhabdomyosarcoma performed with the aim of preserving organ function. Recent findings Bladder–prostate rhabdomyosarcomas are seldom fully resectable at presentation or after induction chemotherapy, and extensive resection might not improve survival. When an organ-sparing approach is pursued, radiotherapy might be unavoidable to achieve reliable local control of the disease. Benefits of preoperative vs. postoperative radiotherapy have yet to be investigated. Multimodal treatments may often result ...
Source: Current Opinion in Urology - Category: Urology & Nephrology Tags: PAEDIATRIC URO-ONCOLOGY: Edited by Manuela P. Hiess Source Type: research
In this study, a radiation response modelling framework for assessing clinical RBE variability is established. It was applied to four selected glioma patients (grade III) treated with adjuvant radio(chemo)therapy and who developed late morphological image changes on T1-weighted contrast-enhanced (T1w-CE) magnetic resonance (MR) images within approximately two years of recurrence-free follow-up. The image changes were correlated voxelwise with dose and linear energy transfer (LET) values using univariable and multivariable logistic reression analysis. The regression models were evaluated by the area-under-the-curve (AUC) pe...
Source: Physics in Medicine and Biology - Category: Physics Authors: Tags: Phys Med Biol Source Type: research
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