Pompholyx-like eruptions induced by penicillamine in a patient with wilson & #39;s disease

Diana Elizabeth Devassy, Sujata Raj Harshad, Harshad DevarbhaiIndian Journal of Dermatology 2019 64(4):321-323 Wilson's disease is an inherited disorder of copper metabolism that results in excessive accumulation of copper in various organs, with liver being the primary site of involvement. D-penicillamine (DPA) as a chelating agent forms the mainstay of therapy; however, it can cause a myriad of adverse effects on long-term use. The major adverse effects reported with DPA include disorders of collagen synthesis, such as pseudoxanthoma elasticum-like lesions, autoimmune blistering diseases, and urticarial lesions. Here, we report a young girl who developed extensive pompholyx-like blisters within a few months of starting DPA which on histopathology showed a spongiotic reaction. The lesions improved on stopping DPA and initiation of oral steroids.
Source: Indian Journal of Dermatology - Category: Dermatology Authors: Source Type: research