Induction of Chronic Subclinical Systemic Inflammation in Sprague –Dawley Rats Stimulated by Intermittent Bolus Injection of Lipopolysaccharide

In conclusion, these results indicate that intermittent exposure to LPS produces chronic subclinical systemic inflammation in multiple organs leading to chronic conditions and supports this model to be a useful preclinical tool for developing immunotherapeutic agents that cou ld prevent, or reduce, chronic inflammatory diseases associated with, or without, bacterial translocation.
Source: Archivum Immunologiae et Therapiae Experimentalis - Category: Allergy & Immunology Source Type: research