Abnormal Auditory Mismatch Fields in Children and Adolescents with 47,XYY Syndrome

This study investigated whether similar findings are observed in XYY-associated ASD and whether delayed processing is also present in individuals with XYYwithout ASD. MEG measured MMFs arising from the left and the right superior temporal gyrus during an auditory oddball paradigm with vowel stimuli (/a/ and /u/) in children/adolescents with XYY both with and without a diagnosis of ASD, as well as in those with ASD-I and in typically developing controls (TD). Ninety male participants (6 –17 years old) were included in the final analyses (TD,n = 38, 11.50 ± 2.88 years; ASD-I,n = 21, 13.83 ± 3.25 years; XYY without ASD,n = 15, 12.65 ± 3.91 years; XYY with ASD,n = 16, 12.62 ± 3.19 years). The groups did not differ significantly in age (p #x3e; 0.05). There was a main effect of group on MMF latency (p #x3c; 0.001). Delayed MMF latencies were found in participants with XYY both with and without an ASD diagnosis, as well as in the ASD-I group compared to the TD group (ps #x3c; 0.001). Furthermore, participants with XYY (with and without ASD) showed a longer MMF latency than the ASD-I group (ps #x3c; 0.001). There was, however, no significant difference in MMF latency between individuals with XYY with ASD and those with XYY without ASD. Delayed MMF latencies were associated with severity of language impairment. Our findings suggest that auditory MMF latency delays are pronounced in this specific Y chromosome aneuploidy disorder, both with and without an ASD diagnosis, and thus ...
Source: Developmental Neuroscience - Category: Neuroscience Source Type: research