Tying up Loose Ends in the Malaria Antigenic Variation Story.

Tying up Loose Ends in the Malaria Antigenic Variation Story.
Trends Parasitol. 2019 Jun 29;:
Authors: Arnot DE
Abstract
A recent paper (Wang et al., PLoS Biol., 2019) shines remarkable new light onto the malaria antigenic variation story. Using CRISPR/Cas9-targeted chromosome breaks and long-read whole-genome sequencing, they followed the fate of detached subtelomeric PfEMP1/var genes and demonstrated that these initiate cascades of recombination at sites far from the original break.
PMID: 31266710 [PubMed - as supplied by publisher]

Source: Trends in Parasitology - June 28, 2019 Category: Parasitology Authors: Arnot DE Tags: Trends Parasitol Source Type: research