Individuals with familial hypercholesterolemia and cardiovascular events have higher circulating Lp(a) levels

Cardiovascular disease (CVD) is a major cause of mortality and morbidity. Increased low-density lipoprotein-cholesterol (LDL-C) level is its major risk factor. Familial Hypercholesterolemia (FH) is a genetic disorder characterized by elevated LDL-C since birth and subsequent premature CVD. There is a heterogeneity in the CVD onset in FH patients. This is potentially due to the presence of other independent risk factors. Lipoprotein(a) [Lp(a)] is an LDL-like particle and represents a strong risk factor for CVD.
Source: Journal of Clinical Lipidology - Category: Lipidology Authors: Source Type: research