Metformin Treatment and Cancer Risk: Cox Regression Analysis with Time-Dependent Covariates of 320,000 Individuals with Incident Diabetes Mellitus.
Metformin Treatment and Cancer Risk: Cox Regression Analysis with Time-Dependent Covariates of 320,000 Individuals with Incident Diabetes Mellitus. Am J Epidemiol. 2019 Jul 03;: Authors: Dankner R, Agay N, Olmer L, Murad H, Boker LK, Balicer RD, Freedman LS Abstract There is conflicting evidence regarding the association between metformin use and cancer risk in diabetic patients. During 2002-2012, we followed a cohort of 315,890 incident diabetic individuals aged 21-87 years insured in the largest health maintenance organization in Israel. We used a discrete form of the weighted cumulative metformin exposure to evaluate its association with cancer incidence. This was implemented in a time-dependent covariate Cox model, adjusting for treatments with other glucose lowering medications, as well as age, sex, ethnic background, socioeconomic status, smoking (for bladder and lung cancer) and parity (for breast cancer). We excluded from the analysis the metformin exposure in the year before cancer diagnosis to minimize reverse causation of cancer on changes in medication. Estimated hazard ratios (HRs) that were associated with exposure to 1 defined daily dose of metformin over the previous 2-7 years were: for all-sites cancer (excluding prostate and pancreas) HR=0.98 (95% confidence interval (CI) 0.82, 1.18); colon cancer, HR=1.05 (95%CI 0.67, 1.63); bladder cancer, HR=0.98 (95%CI 0.49, 1.97); lung cancer, HR=1.02 (95%CI 0.59, 1.78); and female breast cancer, H...
Antipsychotic medications are a vital part of controlling psychosis in schizophrenic patients. However, when those patients live in nursing facilities, we are obligated by CMS to undertake gradual dose reductions of antipsychotic medication if possible. Sometimes, these efforts are successful and sometimes they fail. Antipsychotic medications have many side effects, including sedation, diabetes, hyperlipidemia, weight gain, motor rigidity, impaired gait, and falls. Monitoring of blood glucose, lipids, and extrapyramidal symptoms is mandatory.
Management of diabetes in post-acute settings needs special considerations. Hypoglycemia in the skilled nursing and rehabilitation facilities can lead to readmissions and complications including falls. Current EHR care-sets may not make a distinction between hospital and post-acute settings regarding diabetes management. The current diabetes management care-set in the EHR of our large healthcare system includes checking the blood sugar QID/AC/HS (before breakfast, lunch and dinner, and bedtime).
Authors: Lee YM, Park SH, Lee DH Abstract OBJECTIVE: The aim of this paper is to propose a new hypothesis for the role of lipophilic chemical mixtures stored in adipose tissue in the development of dementia. Specifically, we present how the dynamics of these chemicals can explain the unexpected findings from the Action for Health in Diabetes (Look AHEAD) study, which failed to show long-term benefits of intentional weight loss on cognition, despite substantial improvements in many known risk factors for dementia. Moreover, we discuss how the role of obesity in the risk of dementia can change depending on the dynami...
Hi guys, I'm trying to gauge where I stand and am very confused due to my weird background. I took the MCAT in Jan and received a 524, but my GPAs are on the lower end. I am AA URM. GPA: 3.66c, 3.73s, 1 year 4.0 at end || 3.5 masters, 3.5 PhD first year (left see below) MCAT: 524 || Balanced, first take State: CA Race: URM, AA Clinical Volunteering: 250 hours - general hospital volunteer pulm unit 200 hours - driver for american cancer society patients 280... 3.66 cGPA, 3.73sGPA, 524 MCAT URM
Publication date: Available online 25 February 2020Source: The Lancet Respiratory MedicineAuthor(s): Tony Kirby
Publication date: 2020Source: European Journal of Radiology Open, Volume 7Author(s): Anuradha Chandramohan, Umar M. Siddiqi, Rohin Mittal, Anu Eapen, Mark R. Jesudason, Thomas S. Ram, Ashish Singh, Dipti Masih
Publication date: 1 June 2020Source: Personality and Individual Differences, Volume 159Author(s): Donald H. Saklofske
Publication date: 1 June 2020Source: Personality and Individual Differences, Volume 159Author(s): Shaul Kimhi, Yohanan Eshel, George A. Bonanno
Conclusion: These updated French guidelines will contribute to increase the level of urological care for the diagnosis and treatment for NMIBC and MIBC. PMID: 32093463 [PubMed - in process]
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