A rational free energy-based approach to understanding and targeting disease-causing missense mutations.

CONCLUSIONS: This observation is used to demonstrate, computationally and experimentally, that a particular condition, Snyder-Robinson syndrome caused by the G56S spermine synthase mutation, might be ameliorated by small molecule binding. PMID: 23408511 [PubMed - as supplied by publisher]
Source: Journal of the American Medical Informatics Association - Category: Information Technology Authors: Tags: J Am Med Inform Assoc Source Type: research

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Authors: Eftekharsadat B, Aghamohammadi D, Dolatkhah N, Hashemian M, Salami H Abstract Background: We aimed to determine dietary intake and serum concentration of α-tocopherol and lycopene in subjects with knee osteoarthritis (KOA) in relation to pain intensity and functional status and comparing them with healthy controls. Methods: This case-control study was conducted among 35 patients with primary KOA and 35 matched healthy subjects selected using convenience sampling method. Dietary intakes of alpha-tocopherol and lycopene were estimated from 24-hour dietary records. Visual Analogue Scale (VAS) and Weste...
Source: International Journal for Vitamin and Nutrition Research - Category: Nutrition Tags: Int J Vitam Nutr Res Source Type: research
BACKGROUND: Severe traumatic brain injury (TBI) is associated with high rates of death and disability. As a result, the revised guidelines for the management of pediatric severe TBI address some of the previous gaps in pediatric TBI evidence and management...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news
Traumatic brain injury (TBI) is one of the leading causes of mortality and disability around the world. Mild TBI (mTBI) makes up approximately 80% of reported cases and often results in transient psychological abnormalities and cognitive disruption. At-ris...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. TBIs, which range in severity from mild to severe, occur when a traumatic event, such as a fall, a traffic accident, or a blow, causes the brain to move rapidly within the s...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
Purpose: Earthquake survivors whose physical injuries result in disability may be at increased risk for prolonged and severe post-traumatic stress disorder. We estimated the prevalence of post-traumatic stress disorder, functional limitations, and e...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Disaster Preparedness Source Type: news
Discussion: Since a true short esophagus diagnosis depends on transurgical findings, pediatric surgeons should notice this entity when practicing any antireflux procedure. Laparoscopic Collis-Nissen approach is safe and efficient in these patients. PMID: 31967614 [PubMed - in process]
Source: Cirugia y Cirujanos - Category: Surgery Authors: Tags: Cir Cir Source Type: research
ConclusionThe results of this study showed that besides physical factors such as pain radiation and disability level, which influenced the decision of patients to take the surgical option, patients who were unemployed were also more likely to choose surgery. This indicates that patients were worried about the possible impact of surgery on their employment, or on their ability to continue to work. It is important that patients be given a clear picture of the expected outcomes of their surgery, and that the information needs of patients regarding the surgery be explored and addressed.
Source: International Journal of Orthopaedic and Trauma Nursing - Category: Nursing Source Type: research
This guidance identifies the principles relevant to victims and witnesses with mental health conditions or disorders, namely: A mental disorder, as defined by the 2 External 0 0 0Mental Health Act 2007 false https://www.legislation.gov.uk/ukpga/2007/12/section/1 true false%> A learning disability A learning difficulty Autism Spectrum Disorder An acquired brain injury Dementia Other mental health, cognitive or neuro-diverse conditions. Further information about such conditions can be found at Annex A. This guidance therefore seeks to address a span of conditions which comprise disorders, disabilities, impairments, inj...
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
High dose chemotherapy followed by hematopoietic cell transplantation (HCT) is an intensive cancer treatment associated with devastating complications. Persistent physical inactivity after HCT is sufficient to cause muscle mass loss, decreased strength, physical deconditioning, and potential progression to disability. Sustainable physical activity incorporated into activities of daily living may break this negative cycle. This pilot, randomized controlled trial tested the feasibility and preliminary effects of a free-living physical activity intervention (STEPS) compared to usual care on fatigue (primary outcome), function...
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 110 Source Type: research
Persons with multiple sclerosis (MS) are sometimes treated with high-dose immune suppressive or cytotoxic drugs and an autotransplant. Therapy-related mortality (TRM) has decreased to
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 22 Source Type: research
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