Profiling histone modifications in the normal mouse kidney and after unilateral ureteric obstruction.

In conclusion, our study highlights the importance of unbiased screening in examining histone marks. Simultaneous changes in multiple marks on the same amino acid indicate a coordinated histone mark signature. The heterogeneous enrichment of marks, even within the same tubule, highlights the importance of regulatory context.
PMID: 31268352 [PubMed - as supplied by publisher]

Source: Am J Physiol Renal P... - July 2, 2019 Category: Urology & Nephrology Authors: Hewitson TD, Holt SG, Samuel CS, Wigg B, Smith ER Tags: Am J Physiol Renal Physiol Source Type: research