EIF4G1 is a novel candidate gene associated with severe asthenozoospermia

ConclusionOur experimental findings indicate that the EIF4G1 gene is a novel candidate gene that may be relevant to severe AZS.
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research

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ConclusionCurrent evidence supports interventional therapy as a means to alleviate sperm DNA damage. Identification of the conditions associated with SDF remains important to enable treatment to potentially improve pregnancy outcomes but given the limited data further research is needed to determine the exact role of specific interventional therapy for subfertile men with impaired sperm chromatin.
Source: Andrology - Category: Urology & Nephrology Authors: Tags: REVIEW ARTICLE Source Type: research
AbstractPurposeTo investigate whether the ability of human spermatozoa to decondense in vitro in the presence of heparin (Hep) and glutathione (GSH) is related to assisted reproduction (ART) success.MethodsCross-sectional pilot study involving male partners of 129 infertile couples undergoing ICSI with (45) or without (84) donor oocytes at two infertility clinics in CABA, Argentina, between October 2012 and December 2013. In vitro decondensation kinetics with Hep and GSH and DNA fragmentation (TUNEL) were determined on the same sample used for ICSI. The possible relationship of decondensation parameters (maximum decondensa...
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
CONCLUSIONS: This retrospective cohort study demonstrated that patients who underwent ART were at increased risk of several adverse pregnancy outcomes compared with women who conceived spontaneously. These complications may be attributed in part to the relatively high multiple pregnancy rate after ART. Elective single embryo transfer should be promoted in China to reduce the obstetrical risks of ART pregnancy. Singletons of ART pregnancy exhibited increased maternal and neonatal complications as well, suggesting that underlying infertility or other maternal or parental factors may contribute to the adverse outcomes. P...
Source: Chinese Medical Journal - Category: General Medicine Authors: Tags: Chin Med J (Engl) Source Type: research
AbstractSTUDY QUESTIONCan ovarian biopsyingper se and/or autotransplantation of fragmented ovarian cortical tissue activate dormant follicles and increase the number of recruitable follicles for IVF/ICSI in women with diminished ovarian reserve (DOR)?SUMMARY ANSWEROvarian biopsying followed by immediate autotransplantation of fragmented cortical tissue failed to increase the number of recruitable follicles for IVF/ICSI 10  weeks after the procedure either at the graft site or in the biopsied ovary, but 12 of the 20 women subsequently had a clinical pregnancy during the 1-year follow-up.WHAT IS KNOWN ALREADYInfertile w...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
(Abstracted from Human Reproduction 2019;34(6):1042–1054) Nearly one third of all subfertility causes remain unexplained. In addition, assisted-reproductive technologies (ARTs) such as IVF-ICSI are invasive and only 25% to 35% of women become pregnant after the first embryo transfer (ET).
Source: Obstetrical and Gynecological Survey - Category: OBGYN Tags: GYNECOLOGY: INFERTILITY/REPRODUCTIVE TECHNOLOGIES Source Type: research
Conclusion: Men with AZF microdeletions can achieve the delivery of healthy children using ICSI. In this series, it produced good implantation rate and obstetric and perinatal outcomes.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research
This study discussed the effects of AFC quartile levels on pregnancy outcomes combined with female age, female cause of infertility, and ovarian response undergoing in vitro fertilization (IVF) treatment. At present, many research about AFC mainly discuss its impact on clinical practice at different thresholds, or the analyses of AFC with respect to assisted reproductive technology outcomes under using different ovarian stimulation protocols. Factors that include ovarian sensitivity index, female age, and infertility cause are all independent predictors of live birth undergoing IVF/intracytoplasmic sperm injection, while f...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
ConclusionsOur results suggested that maternal background and obstetric parameters could strongly influence the SGA rate than fresh-ET conception. Similarly, our results FET conception could be associated with an increase of LGA rate in the fetus, especially in cases of female infertility.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
Couples are classified as having unexplained infertility when they have tried to conceive for at least one year and no abnormality in semen analysis, ovulation, or tubal patency has been identified. Treatment options for unexplained infertility include expectant management, ovarian stimulation (OS), intrauterine insemination (IUI), OS-IUI, and in vitro fertilisation (IVF) with or without intracytoplasmic sperm injection (ICSI). Cochrane authors conductednetwork meta-analysis on interventions for unexplained infertility.Cochrane Gynecology and Fertility sat down with Dr Rui Wang, the lead author of the study, who answered t...
Source: Cochrane News and Events - Category: Information Technology Authors: Source Type: news
Abstract Sperm DNA fragmentation (SDF) has been linked with male infertility, and previous studies suggest that SDF can have negative influence on pregnancy outcomes with assisted reproduction. We performed a retrospective review of consecutive couples with a high SDF level that had intracytoplasmic sperm injection (ICSI) using testicular sperm (T-ICSI). We compared the T-ICSI outcomes to that of two control groups: 87 couples with failed first ICSI cycle and who had a second ICSI cycle using ejaculated sperm (Ej-ICSI), and 48 consecutive couples with high sperm chromatin structure assay (SCSA)-defined SDF (>15...
Source: Asian Journal of Andrology - Category: Urology & Nephrology Authors: Tags: Asian J Androl Source Type: research
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