Repeatability of tumor blood flow quantification with 82 Rubidium PET/CT in prostate cancer  — a test-retest study

ConclusionDynamic82Rb PET/CT with kinetic modeling measures TBF in prostate cancer with high repeatability, which allows identification of blood flow changes of 32%. Static late-uptake82Rb PET/CT is inferior, and only intra-individual blood flow changes above 51% can hence be recognized.
Source: EJNMMI Research - Category: Radiology Source Type: research

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Pre-treatment ratio of periprostatic to subcutaneous fat thickness on MRI is an independent survival predictor in hormone-naïve men with advanced prostate cancer. Int J Clin Oncol. 2019 Oct 15;: Authors: Sasaki T, Sugino Y, Kato M, Nishikawa K, Kanda H Abstract BACKGROUND: Epidemiological studies have shown an association between obesity and prostate cancer (PCa) aggressiveness. However, little is known about periprostatic fat (PPF) and its relationship with overall fat deposition in PCa. PPF is thought to contribute to PCa growth and migration via secreted factors and induction of chronic inflam...
Source: Clinical Prostate Cancer - Category: Cancer & Oncology Authors: Tags: Int J Clin Oncol Source Type: research
AbstractBackgroundEpidemiological studies have shown an association between obesity and prostate cancer (PCa) aggressiveness. However, little is known about periprostatic fat (PPF) and its relationship with overall fat deposition in PCa. PPF is thought to contribute to PCa growth and migration via secreted factors and induction of chronic inflammation. We investigated if pre-treatment PPF thickness correlates with overall survival (OS).MethodsWe reviewed 85 hormone-na ïve men with advanced PCa who had received androgen deprivation therapy (ADT). PPF thickness was measured by magnetic resonance imaging (MRI) and compar...
Source: International Journal of Clinical Oncology - Category: Cancer & Oncology Source Type: research
This study investigates and optimizes the BAD map approach for sCT quality assurance with a large patient CT and MRI dataset. 3D T2-weighted MRI and full density CT images of 54 patients were used to create BAD maps with different tissue class combinations. Mean Hounsfield units (HU) of Fat (F: below −30 HU), the entire Tissue [T: excluding bone (B)], and Muscle (M: excluding bone and fat) were derived from the CT scans. CT based BAD maps (BADBT,CT and BADBMF,CT) and a conventional bone and water bulk-density method (BADBW,CT) were compared to full CT calculations with bone assignments to 366 HU (measured) and 288 HU...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Authors: Zimmerman ME, Meyer AR, Rowe SP, Gorin MA Abstract Prostate cancer is most commonly imaged through a combination of magnetic resonance imaging, x-ray computed tomography, and 99mTc-methylene diphosphonate bone scan. These conventional imaging modalities, however, suffer from limited sensitivity and specificity for the detection of disease. This can lead to disease understaging and the improper selection of treatment. To address this problem, a variety of novel radiotracers for positron emission tomography (PET) imaging have been developed. This includes agents that accumulate on the basis of alterations in...
Source: Clinical Advances in Hematology and Oncology - Category: Cancer & Oncology Tags: Clin Adv Hematol Oncol Source Type: research
Conclusions: Early assessment of PSA after surgery is important for predicting radiographic progression in node-positive prostate cancer patients. Risk stratification based on the early PSA value after surgery would be helpful to identify patients who may benefit from early adjuvant therapies.
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Paper Source Type: research
Conclusions: TBF measured using static 82Rb PET/CT in prostate cancer can be reproduced with a coefficient of variance and repeatability of approximately 20% and 55%, respectively, depending on SUV measure. Consequently, the method can be applied to monitor relative changes in TBF above 55% in serial exams. Financial support This work was financially supported by The Danish Cancer Society, Health Research Fund of Central Denmark Region, P. Carl Petersens Fond, Dansk Kræftforskningsfond and Knud og Edith Eriksens Mindefond.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Prostate/GU Imaging Posters Source Type: research
1567Objectives: 18F-rhPSMA-7 is a new PSMA-targeting agent which can be efficiently labeled with 18F and radiometals and is associated with only minimal renal excretion. Here, we preset the results of a retrospective analysis of the efficacy of 18F-rhPSMA-7 positron emission tomography (PET) for primary N-staging compared with morphological imaging (computed tomography [CT] or magnetic resonance imaging [MRI]) and validated by histopathology. Methods: Data from patients with high risk prostate cancer (defined by D’Amico) who were staged with 18F-rhPSMA-7 PET/CT or PET/MRI at our institutions between July 2017 and Jun...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Prostate/GU Imaging Posters Source Type: research
Conclusions: PSMA imaging detected unknown sites of disease in more than half of patients with BCR prostate cancer in this cohort. All positive findings on conventional imaging were also positive on PSMA imaging.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Prostate/GU Imaging Posters Source Type: research
Conclusions: 68Ga-PSMA PET/CT provided superior detection of locoregional preoperative staging of PC as compared to mpMRI in intermediate and high risk prostate cancer patients.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Prostate/GU Imaging Posters Source Type: research
Conclusions The recent, first randomized clinical trial demonstrated overall and progression free survival benefits after SBRT to oligometastatic disease which supports prior retrospective case series (6). The spine is a common site of metastatic bone disease, and as high quality data continue to mature, along with completion of additional randomized clinical trials, it is expected that utility of SBRT to the spine will increase in the future. Spine SBRT is unique due to the requirement of sharp dose falloff to prevent serious neurologic morbidity. With recent advances in radiotherapy planning, robotic patient positionin...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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