Levetiracetam Protects Against Cognitive Impairment of Subthreshold Convulsant Discharge Model Rats by Activating Protein Kinase C (PKC)-Growth-Associated Protein 43 (GAP-43)-Calmodulin-Dependent Protein Kinase (CaMK) Signal Transduction Pathway.

CONCLUSIONS</strong> Cognitive impairment in of SCD model rats may be caused by decreased PKC activity, low expression of CaMK II, and inhibition of LTP formation. LEV can improve cognitive function by activating the PKC-GAP-43-CaMK signal transduction pathway. PMID: 31266934 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/31266934?dopt=Abstract

Source: Medical Science Monitor - July 4, 2019 Category: Research Tags: Med Sci Monit Source Type: research