Voluntary exercise reduces plasma cortisol levels and improves transitory memory impairment in young and aged Octodon degus.

In this study, animals had free individual access to wheels to practice voluntary exercise. The Barnes Maze (BM) task was conducted with young and aged O. degus animals after combining voluntary exercise and either normal sleep or SD. Plasma cortisol levels were measured after each condition. SD impaired hippocampus-dependent memory in both young and old animals, while cortisol levels did not significantly differ between non-SD and SD animals. However, voluntary exercise for 45 days improved the cognitive impairment caused by SD compared with the control condition. Moreover, voluntary exercise decreased plasma cortisol levels in both conditions, independently of the age. PMID: 31269420 [PubMed - as supplied by publisher]
Source: Behavioural Brain Research - Category: Neurology Authors: Tags: Behav Brain Res Source Type: research

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DiscussionWPNs are extremely vulnerable to AD but not to 4 repeat tauopathies. Considering that WPNs are involved early in AD, such degeneration should be included in the models explaining sleep-wake disturbances in AD and considered when designing a clinical intervention. Sparing of WPNs in PSP, a condition featuring hyperinsomnia, suggest that interventions to suppress the arousal system may benefit patients with PSP.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
Previously, it was unclear if disturbed sleep put people at risk of Alzheimer's - or if disease-related brain changes lead to it. A new study by UCSF shows dementia crushes brain cells that keep us awake.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Initial results from a feasibility study conducted by Eli Lilly and Company (NYSE: LLY), Evidation Health, and Apple Inc. (NASDAQ: AAPL) showed that an iPhone, Apple Watch, iPad and the Beddit sleep monitoring device, in combination with digital apps may be able to differentiate people with mild cognitive impairment (MCI) and mild Alzheimer's disease dementia.
Source: World Pharma News - Category: Pharmaceuticals Tags: Featured Eli Lilly and Company Business and Industry Source Type: news
Initial results from a feasibility study conducted by Eli Lilly and Company (NYSE: LLY), Evidation Health, and Apple Inc. (NASDAQ: AAPL) showed that an iPhone, Apple Watch, iPad and the Beddit sleep monitoring device, in combination with digital apps may be able to differentiate people with mild cognitive impairment (MCI) and mild Alzheimer's disease dementia.
Source: eHealth News EU - Category: Information Technology Tags: Featured Industry Business and Industry Source Type: news
Gradual memory loss, cognitive decline, wandering off to unknown places, being unable to dress in the morning: to live with dementia and Alzheimer’s disease might be a heart-wrenching burden for both patients and their loved ones. As the global population ages, and the number of individuals suffering from these conditions rises, digital technologies must step forward and offer some solutions for early detection and disease management. That’s what we examined in detail here, so let’s see the intersections of digital health and Alzheimer’s disease. Have you seen Aurora Borealis? Your mind can pl...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Medicine alzheimer Alzheimer's disease brain cognitive health dementia digital digital health elderly elderly care Healthcare Innovation medical technology Source Type: blogs
This study elucidates the potential to use mitochondria from different donors (PAMM) to treat UVR stress and possibly other types of damage or metabolic malfunctions in cells, resulting in not only in-vitro but also ex-vivo applications. Gene Therapy in Mice Alters the Balance of Macrophage Phenotypes to Slow Atherosclerosis Progression https://www.fightaging.org/archives/2019/07/gene-therapy-in-mice-alters-the-balance-of-macrophage-phenotypes-to-slow-atherosclerosis-progression/ Atherosclerosis causes a sizable fraction of all deaths in our species. It is the generation of fatty deposits in blood vessel...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
This article is excerpted from Roberts &Kreuz’s book “Becoming Fluent: How Cognitive Science Can Help Adults Learn a Foreign Language.” This article originally appeared on MIT Press Reader. Read the original article here.  
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Aging syndication Source Type: news
Swedish and Canadian researchers have developed a four-stage model that uses...Read more on AuntMinnie.comRelated Reading: PET shows how women are more susceptible to Alzheimer's Florbetapir-PET links lack of financial acumen to dementia IDEAS study confirms amyloid PET's value for Alzheimer's Are amyloid PET scans ready for the clinical setting? PET links sleep and beta-amyloid accumulation
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
This popular science article from the AARP is representative of the sort of outsider's view of the longevity industry that is presently dominant. On the one hand, it is good that the media and advocacy organizations such as AARP are finally talking seriously about treating aging as a medical condition. On the other hand, the author looks at two of the most popular areas of development, mTOR inhibitors and senolytics, in a way that makes them seem more or less equivalent, and then further adds diet and exercise as another equivalent strategy. This will be continuing issue, I fear. People, as a rule, don't think about size o...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Abstract Alzheimer's disease (AD), which accounts for most of the dementia cases, is, aside from cognitive deterioration, often characterized by the presence of non-cognitive symptoms such as activity and sleep disturbances. AD patients typically experience increased sleep fragmentation, excessive daytime sleepiness and night-time insomnia. Here, we sought to investigate the link between sleep architecture, cognition and amyloid pathology in the APP23 amyloidosis mouse model for AD. By means of polysomnographic recordings the sleep-wake cycle of freely-moving APP23 and wild-type (WT) littermates of 3, 6 and 12 mon...
Source: Behavioural Brain Research - Category: Neurology Authors: Tags: Behav Brain Res Source Type: research
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