The role of chitosan as coating material for nanostructured lipid carriers for skin delivery of fucoxanthin

Publication date: 15 August 2019Source: International Journal of Pharmaceutics, Volume 567Author(s): Leticia Malgarim Cordenonsi, Angela Faccendini, Michele Catanzaro, Maria Cristina Bonferoni, Silvia Rossi, Lorenzo Malavasi, Renata Platcheck Raffin, Elfrides Eva Scherman Schapoval, Cristina Lanni, Giuseppina Sandri, Franca FerrariAbstractFucoxanthin (FUCO) is a marine carotenoid characterized by antiproliferative properties against hyperproliferative cells. The aim of this work was to design and develop nanostructured lipidic carriers (NLCs) based on bacuri butter and tucumã oil and loaded with FUCO, intended for skin application to prevent skin hyperproliferative diseases and in particular psoriasis. The presence of FUCO should control the hyperproliferation of skin diseased cells and the lipids forming the NLC core, rich in antioxidants and characterized by wound healing properties, should favor the restoring of skin integrity. NLCs were coated with chitosan (CS) to improve their biopharmaceutical properties (bio/mucoadhesion and wound healing) and to combine the advantages of lipidic nanoparticles with the biological properties of CS. Chitosan coated and non-coated NLC were prepared by means of high shear homogenization and characterized for chemico-physical and biopharmaceutical properties (in vitro biocompatibility and cell uptake towards normal dermal human fibroblasts). Moreover, the pharmacological activity of FUCO loaded in NLCs was assessed in psoriatic-like cellu...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research