Associations of Neprilysin Activity in CSF with Biomarkers for Alzheimer's Disease.

CONCLUSIONS: Our results on CSF-NEP are compatible with the assumption that local degradation, amongst other mechanisms of amyloid clearance, plays a role in the development of Alzheimer's pathology. In addition, CSF-NEP is associated with the extent and the rate of neurodegeneration. PMID: 31266021 [PubMed - as supplied by publisher]
Source: Neuro-Degenerative Diseases - Category: Neurology Authors: Tags: Neurodegener Dis Source Type: research

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by Jee Wook Kim, Min Soo Byun, Dahyun Yi, Jun Ho Lee, Kang Ko, So Yeon Jeon, Bo Kyung Sohn, Jun-Young Lee, Yu Kyeong Kim, Seong A Shin, Chul-Ho Sohn, Dong Young Lee, for the KBASE Research Group BackgroundAn emerging body of literature has indicated that moderate alcohol intake may be protective against Alzheimer disease (AD) dementia. However, little information is available regarding whether moderate alcohol intake is related to reductions in amyloid-beta (A β) deposition, or is protective via amyloid-independent mechanisms in the living human brain. Here we examined the associations of moderate alcohol intake with ...
Source: PLoS Medicine - Category: Internal Medicine Authors: Source Type: research
This cross-sectional, longitudinal study of amyloid- β–positive individuals with mild cognitive impairment or Alzheimer disease dementia examines the factors associated with interindividual differences in brain and cognitive resilience to tau positron emission tomography load and to changes in global cognition over time.
Source: JAMA Neurology - Category: Neurology Source Type: research
The objective of this work was to determine the effects of this drug on human erythrocytes, which have a type of AChE in the cell membrane. To that end, human erythrocytes and molecular models of its membrane constituted by dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylethanolamine (DMPE) were used. They correspond to classes of phospholipids present in the outer and inner monolayers of the human erythrocyte membrane, respectively. The experimental results obtained by X-ray diffraction and differential scanning calorimetry (DSC) indicated that rivastigmine molecules were able to interact with both phosph...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
Molecules, Vol. 25, Pages 982: Revisiting the Radiosynthesis of [18F]FPEB and Preliminary PET Imaging in a Mouse Model of Alzheimer’s Disease Molecules doi: 10.3390/molecules25040982 Authors: Cassis Varlow Emily Murrell Jason P. Holland Alina Kassenbrock Whitney Shannon Steven H. Liang Neil Vasdev Nickeisha A. Stephenson [18F]FPEB is a positron emission tomography (PET) radiopharmaceutical used for imaging the abundance and distribution of mGluR5 in the central nervous system (CNS). Efficient radiolabeling of the aromatic ring of [18F]FPEB has been an ongoing challenge. Herein, five metal-free p...
Source: Molecules - Category: Chemistry Authors: Tags: Communication Source Type: research
ConclusionsCustomized FreeSurfer-based brain atlas for DARTEL tool is easy to create and useful for the analysis of PET and MR images with high adaptability and reliability for broad research purposes.
Source: Annals of Nuclear Medicine - Category: Nuclear Medicine Source Type: research
The objective of this work was to determine the effects of this drug on human erythrocytes, which have a type of AChE in the cell membrane. To that end, human erythrocytes and molecular models of its membrane constituted by dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylethanolamine (DMPE) were used. They correspond to classes of phospholipids present in the outer and inner monolayers of the human erythrocyte membrane, respectively. The experimental results obtained by X-ray diffraction and differential scanning calorimetry (DSC) indicated that rivastigmine molecules were able to interact with both phosph...
Source: Chemico-Biological Interactions - Category: Molecular Biology Authors: Tags: Chem Biol Interact Source Type: research
CONCLUSIONS: Brain 18F-FDG PET had an elevated performance in the early diagnosis of PPA variants and in the advanced PPA AD/FTD classification. QL clarified the development of AD or FTD in advanced PPA cases and supported the differential diagnosis of a PPA variant in a few early cases. QN 18F-FDG PET evaluation better contributed to the early diagnosis of an unclear metabolic pattern. To correctly identify all cases, patients with diffuse cortical hypometabolism were also included. Larger series are necessary to confirm these data. PMID: 32062656 [PubMed - as supplied by publisher]
Source: Dementia and Geriatric Cognitive Disorders - Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research
When PET scans reveal elevated amyloid levels in cognitively normal older adults,...Read more on AuntMinnie.comRelated Reading: FDG-PET shows where exercise could stall Alzheimer's PET, MRI link amyloid plaque with swift decline Who should get brain scans for Alzheimer's disease? PET, MRI show physical activity aids brain health Would high amyloid level spur physician-assisted death?
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
This article was corrected online.
Source: JAMA Neurology - Category: Neurology Source Type: research
AbstractAccurate, automated white matter hyperintensity (WMH) segmentations are needed for large-scale studies to understand contributions of WMH to neurological diseases. We evaluated Bayesian Model Selection (BaMoS), a hierarchical fully-unsupervised model selection framework for WMH segmentation. We compared BaMoS segmentations to semi-automated segmentations, and assessed whether they predicted longitudinal cognitive change in control, early Mild Cognitive Impairment (EMCI), late Mild Cognitive Impairment (LMCI), subjective/significant memory concern (SMC) and Alzheimer ’s (AD) participants. Data were downloaded ...
Source: Neuroinformatics - Category: Neuroscience Source Type: research
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