Hereditary diffuse gastric cancer: cancer risk and the personal cost of preventive surgery

The objective of this research was to examine post-surgical clinical outcomes and to identify which of the domains/symptoms from the European Organisation for Research and Treatment of Cancer QOL Questionnaire (EORTC QLQ-C30) were determinants of overall quality of life (QOL) in individuals undergoing PTG. Participants were recruited through multiple sources. Postsurgical clinical outcomes were obtained from hospital records. Participants completed validated questionnaires measuring generic and condition specific QOL (PROMIS, EORTC and SF 36v.II) at a single point in time. The mean QOL in this cohort was 70.6 (SD  = 25.6), which is better than reference values from the general populations in USA and Canada Role and social function plus the symptoms anxiety, pain, taste, dyspnea and diarrhea were significant predictor variables for QOL (p 
Source: Familial Cancer - Category: Cancer & Oncology Source Type: research

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CONCLUSIONS In a summary, by inhibiting the STAT3 activation, esculetin shows potential anticancer effects against the laryngeal cancer. PMID: 31630150 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
RESUMO Objetivo Avaliar o efeito do internato em sa úde mental nas atitudes dos alunos de medicina quanto ao portador de transtorno mental (PTM). Métodos Atitudes foram avaliadas por questionário antes e depois do internato, por meio dos fatores: “ aceita ção social de PTM ” (F1), “ n ão acreditar em causas sobrenaturais para doença mental ” (F2), “ pap éis sociais comuns para PTM ” (F3), “ acreditar em causas psicossociais para doen ça mental ” (F4), “ intimidade ” (F5). Diferen ças foram avali...
Source: Jornal Brasileiro de Psiquiatria - Category: Psychiatry Source Type: research
His research brought an end to radical mastectomy, and he pioneered the design and implementation of large-scale multi-institutional randomized clinical trials.Medscape Medical News
Source: Medscape Hematology-Oncology Headlines - Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news
The current clinical study is aimed at evaluating the clinical relevance of an innovative device (called CyPaM2 device) that for the first ...
Source: Journal of the Optical Society of America A - Category: Physics Authors: Source Type: research
Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
Publication date: Available online 20 October 2019Source: Protein Expression and PurificationAuthor(s): Lei Jing, Juanjuan Liu, Dongxu Cui, Yuyin Li, Zhenxing Liu, Li Tao, Qing Zhao, Aipo DiaoAbstractAn affibody is a 58 amino acids peptide derived from the Z domain of staphylococcal protein A and generally applied in areas such as imaging diagnosis, clinical therapeutics and biotechnology research. To screen for an affibody targeting the immune checkpoint PD-L1, a combinatorial affibody library was generated in yeast using degenerate overlap PCR primers and In-fusion technology. Z-j1 and Z-j2 affibodies targeting the Ig-li...
Source: Protein Expression and Purification - Category: Biochemistry Source Type: research
Publication date: Available online 21 October 2019Source: Inorganic Chemistry CommunicationsAuthor(s): Jing Xu, Lan Bai, Yi-Ying Gu, Fan Du, Wen-Yao Zhang, Miao He, Yun-Jun LiuAbstractThree iridium(III) complexes [Ir(ppy)2(DQPC)](PF6) (Ir-1), [Ir(bzq)2(DQPC)](PF6) (Ir-2) and [Ir(piq)2(DQPC)](PF6) (Ir-3) were synthesized and characterized. The cytotoxicity in vitro of the ligand DQPC and complexes Ir-1, Ir-2 and Ir-3 against cancer cells HeLa, A549, HepG2 and normal cell NIH3T3 was assessed by MTT methods. These complexes exhibit significant inhibitory effect on HeLa cells growth with an IC50 value of 2.4 ± 0.2, 2.4 ...
Source: Inorganic Chemistry Communications - Category: Chemistry Source Type: research
Publication date: Available online 20 October 2019Source: Colloids and Surfaces A: Physicochemical and Engineering AspectsAuthor(s): Shun Yang, Jie Fan, Shiting Lin, Yaru Wang, Chang LiuAbstractAlthough the biodegradability of silica has been verified, the complete and safe excretion of mesoporous silica nanoparticles (MSNs) from the biological system still impede their clinical translation. Herein, novel pH-responsive biodegradable hollow mesoporous organosilica nanoparticles (PBHMONs) based on pH-responsive silsesquioxane were successfully prepared for efficient anti-cancer drug delivery. pH-responsive cleavable bridges ...
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Category: Chemistry Source Type: research
Hydrogels are hydrophilic three-dimensional networks able to hold large amount of water and hydrophilic molecules. Magneto-responsive hydrogels comprise of magnetic nanoparticles dispersed in polymeric networks that can be manipulated under external magnetic field. This review aims at (i) giving a brief overview on the evolution of hydrogels until the design and development of magnetic hydrogels; (ii) describing the types of hydrogels and the basic concepts about superparamagnetic iron oxide nanoparticles, as well as the preparation and characterization of magneto-responsive hydrogels; (iii) displaying the relevant applica...
Source: Journal of the Brazilian Chemical Society - Category: Chemistry Source Type: research
Phytochemical study of Sinningia reitzii (Gesneriaceae) led to the isolation of three new naphtoquinones, 6,7-dimethoxydunnione, 7-hydroxy-6-methoxydunnione, and 5-hydroxy-6,7-dimethoxydunnione from the tubers, together with four known compounds, 7-hydroxydunnione, 8-hydroxydunnione, 5-hydroxy-6,7-dimethoxy- α -dunnione, and 8-hydroxydeydrodunnione. Aerial parts furnished five known compounds, 5-hydroxy-6,7-dimethoxydunniol, 6,8-dihydroxy-7-methoxy-2-O-methyldunniol, loureirin B, jacaranone, and methyl 4-hydroxyphenylacetate. Compounds 8-hydroxydunnione, 5-hydroxy-6,7-dimethoxy- α -dunnione, 8-hydroxydeydrodunn...
Source: Journal of the Brazilian Chemical Society - Category: Chemistry Source Type: research
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