MicroRNAs fingerprint of bicuspid aortic valve

Aortic valve tissue is largely exposed to high blood flow. Cells belonging to aortic valve tissues are able to detect and respond to flow conditions changes. Bicuspid aortic valve (BAV) presents altered morphology, with only two abnormal cusps instead of three. This results in an alteration of blood flow dynamics on valve cusps and aortic wall, which may, in turn, increase the risk to develop aortic stenosis and/or regurgitation, endocarditis, aortopathy and/or aortic dissection.MicroRNAs (miRNAs) are short RNA strands regulating gene expression mainly through the inhibition of their target mRNAs.

Source: Journal of Molecular and Cellular Cardiology - July 2, 2019 Category: Cytology Authors: Sabatino Jolanda, Wicik Zofia, DeRosa Salvatore, Eyileten Ceren, Jakubik Daniel, Carmen Spaccarotella, Annalisa Mongiardo, Postula Marek, Indolfi Ciro Source Type: research