Perinatal and postweaning diets high in omega-3 fatty acids have age- and sex-specific effects on the fatty acid composition of the cerebellum and brainstem of C57BL/6 mice

The brain is a highly sophisticated and complex organ that is organized into several regions governing specific functions. The caudocranial developmental timeline of the brain is marked by morphological, structural, and cellular changes [1]. Approximately 60% of the brain's white and gray matter structural component is lipid [2]. In addition, the white and gray matter of the cerebellum and brainstem has a specific fatty acid composition, which has been shown to change during development [3]. The white matter, which contains myelinated axons, is highly enriched in saturated fatty acids (SFA) and monounsaturated fatty acids (MUFA) and contains lower amounts of polyunsaturated fatty acids (PUFA) [4 –6].
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - Category: Biomedical Science Authors: Source Type: research