Aging and FADS1 polymorphisms decrease the biosynthetic capacity of long-chain PUFAs: A human trial using [U-13C]linoleic acid

Long-chain polyunsaturated fatty acids (LCPUFAs), such as arachidonic acid (ARA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), have 20 –22 carbons with 3–6 double bonds. They are important components of biomembranes in most cells, and they have numerous cellular functions, including modulation of membrane fluidity, membrane enzyme activities, and physiological responses, some of which are induced by the formation of lipid media tors from LCPUFAs themselves and the regulatory effects on transcription factors [1–4].

Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - July 2, 2019 Category: Biomedical Science Authors: Hideyuki Sasaki, Toshiaki Sueyasu, Hisanori Tokuda, Mika Ito, Yoshihisa Kaneda, Tomohiro Rogi, Hiroshi Kawashima, Sayaka Horiguchi, Terue Kawabata, Hiroshi Shibata Source Type: research