Akkermansia muciniphila abundance is lower in severe obesity but its increased level after bariatric surgery is not associated with metabolic health improvement.

Akkermansia muciniphila abundance is lower in severe obesity but its increased level after bariatric surgery is not associated with metabolic health improvement. Am J Physiol Endocrinol Metab. 2019 Jul 02;: Authors: Dao MC, Belda E, Prifti E, Everard A, Kayser BD, Bouillot JL, Chevallier JM, Pons N, Le Chatelier E, Ehrlich D, Doré J, Aron-Wisnewsky J, Zucker JD, Cani PD, Clément K Abstract The gut bacterial species, Akkermansia muciniphila is associated with a healthier clinical profile. The purpose of this study was to determine the association between A. muciniphila and glucose homeostasis in patients undergoing bariatric surgery (BS): gastric banding (GB) or Roux-en-Y gastric bypass (RYGB). This non-randomized prospective study included 65 women with severe obesity. Longitudinal analysis included subjects for whom A. muciniphila data was available at follow up (1, 3, and 12 months; GB (N=10) or RYGB (N=11)). Glucose homeostasis markers were measured under fasting or during an oral glucose tolerance test. Fecal microbiota was analyzed using shotgun metagenomics, and A. muciniphila relative abundance was assessed with 16S rRNA qPCR. A. muciniphila relative abundance was significantly lower in severe obesity (BMI mean (SD) 45.7 (5.4) kg/m2) than moderate obesity (33.2 (3.8) kg/m2) but not associated with glucose homeostasis markers. A significant increase in A. muciniphila relative abundance after RYGB was not correlated with metab...
Source: American Journal of Physiology. Endocrinology and Metabolism - Category: Physiology Authors: Tags: Am J Physiol Endocrinol Metab Source Type: research