Is the number of oocytes aspirated after ovarian stimulation for IVF/ICSI associated with the number of top/good quality embryos? A systematic review and meta-analysis

Publication date: Available online 3 July 2019Source: Reproductive BioMedicine OnlineAuthor(s): Belinda G. Vermey, Su Jen Chua, Mohammad Hadi Zafarmand, Rui Wang, Salvatore Longobardi, Evelyn Cottell, Francois Beckers, Ben W. Mol, Christos A. Venetis, Thomas D'HoogheAbstractThe aim of this systematic review and meta-analysis was to determine the association between the number of oocytes aspirated after ovarian stimulation and the number of top/good quality embryos in women undergoing ovarian stimulation for IVF/ICSI. MEDLINE, EMBASE, Scopus, CINAHL and Web of Science were searched for publications reporting on the number of top/good quality embryos, either at the cleavage (Day 2/3) and/or blastocyst (Day 5/6) developmental stage published in English up to November 18, 2017. Twenty-eight studies (three prospective and 25 retrospective) reporting data on 291,752 ART cycles were considered eligible. We confirmed a strong positive association between the number of oocytes retrieved and the number of top/good quality Day 2/3 embryos (17 studies; weighted correlation coefficient [rw=0.791), Day 5/6 embryos (rw=0.901), MII oocytes (rw=0.988), 2PN oocytes (rw=0.987) and euploid embryos (rw= 0.851); P<0.001 for all correlations. Data from 5657 cycles showed the group with the highest number of oocytes aspirated had higher top/good quality Day 2/3 embryos (pooled standardized mean differences: high (>15) vs. low (<4) 1.91, 95% CI 0.5–2.77, P<0.0001; high vs. medium (4–1...
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research