8. Mate pair sequencing characterization of 5q/7q co-deleted acute myeloid leukemia: a prospective study to discover novel co-abnormalities in complex karyotypes
Acute myeloid leukemia (AML) with myelodysplasia-related changes often is associated with a poor prognosis, particularly in the presence of deletions of the long arms of chromosomes 5 and 7. When these deletions co-occur, overall genomic profiles tend to harbor a higher number of structural rearrangements compared to other AML subtypes, and have thus been frequently categorized as having a “complex karyotype” by conventional cytogenetics.
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Beth Pitel, Cinthya Zepeda-Mendoza, Stephanie Smoley, Kathryn Pearce, Ivy Luoma, Roman Zenka, Rhett Ketterling, Nicole Hoppman, Jess Peterson, Patricia Greipp, Linda Baughn Source Type: research
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