49. A single institution experience of CRLF2 rearranged pediatric acute lymphoblastic leukemia/lymphoma

B-lymphoblastic leukemia/lymphoma (B-ALL) BCR-ABL1-like (Ph-like) is a provisional entity in the 2016 revision of the WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. The incidence of Ph-like ALL is 15-30% in children and young adults with B-ALL. Genetic abnormalities associated with Ph-like ALL are heterogenous. Approximately 50% of Ph-like ALL patients may have cytokine receptor like factor 2 (CRLF2) gene overexpression, JAK2 mutations with activation of JAK-STAT pathway and a poor clinical outcome.

Source: Cancer Genetics and Cytogenetics - March 31, 2019 Category: Genetics & Stem Cells Authors: Rebecca B. Smith, Amibeth E. Hollis, Anna Hodge, Melissa Straub, Caitlin Hughes, Ashwini Yenamandra Source Type: research