Diagnostic criteria for limbal stem cell deficiency prior to surgical intervention - A systematic literature review and analysis

An accurate diagnosis of limbal stem cell deficiency (LSCD) is the premise of an appropriate treatment. However, there is no consensus about the diagnostic criteria for LSCD. We performed a systematic literature search of the peer-reviewed articles on PubMed, Medline, and Ovid to investigate how LSCD was diagnosed prior to surgical intervention. The methods used to diagnose LSCD were collected including clinical presentation, impression cytology (IC) and in vivo confocal microscopy (IVCM). Among 131 eligible studies (4054 eyes), 26 studies (459 eyes, 11.3%) did not mention the diagnostic criteria.

Source: Survey of Ophthalmology - July 1, 2019 Category: Opthalmology Authors: Qihua Le, Tulika Chauhan, Sophie X. Deng Tags: Major review Source Type: research