The Relationship between Ferroptosis and Tumors - A Novel Landscape for Therapeutic Approach.

The Relationship between Ferroptosis and Tumors - A Novel Landscape for Therapeutic Approach. Curr Gene Ther. 2019 Jun 28;: Authors: Xia X, Fan X, Zhao M, Zhu P Abstract Ferroptosis is a newly discovered form of iron-dependent oxidative cell death characterized by accumulating lipid-based reactive oxygen species (ROS) to a lethal level. It is distinct from other forms of cell death including apoptosis, necrosis and auto-phage in the aspects of morphology, biochemistry and genetics. Ferroptosis could be triggered by system xc- inhibitors or GHx4 inhibitors, as well as drugs such as sorafenib, SAS, and ART. Recently, studies have demonstrated that ferroptosis was critical in regulating tumor growth, such as hepatocellular carcinoma(HCC), renal cell carcinoma(RCC), non-small cell lung cancer(NSCLC), ovarian cancer, pancreatic carcinoma, diffuse large B cell lymphoma(DLBCL) etc; Ferroptosis was further exhibited to be associated with the resistance of chemotherapeutic drugs. Here in this review, we made an overview by summarize the mechanism of ferroptosis and its relationship with different type of tumors, so as to advance our understanding of cell death and to find a new promising way of clinical cancer management. PMID: 31264548 [PubMed - as supplied by publisher]
Source: Current Gene Therapy - Category: Genetics & Stem Cells Authors: Tags: Curr Gene Ther Source Type: research