Systemic Reactions to Subcutaneous Immunotherapy (SCIT): Effects of Dosing and Aeroallergen Content

Subcutaneous allergen immunotherapy (SCIT) is effective for allergic rhinitis, allergic conjunctivitis, and allergic asthma1. Local reactions are the most common adverse effect associated with SCIT1, though systemic reactions to SCIT (SCITSR) are the most serious adverse effect1. The rate of systemic reactions to SCIT with a conventional dosing schedule is reported to be 0.1-0.2% per injection.1,2 It is generally accepted that the potential benefits of SCIT for select atopic conditions outweigh this risk of SCITSR.

Source: Annals of Allergy, Asthma and Immunology - July 1, 2019 Category: Allergy & Immunology Authors: S Shahzad Mustafa, Theresa Bingemann, Holly Blue, Kelly Conn, Todd Hanley, Allison Ramsey Source Type: research