Neuroinflammation and Schizophrenia

AbstractPurpose of ReviewThere are longstanding, intriguing findings of immune dysfunction in schizophrenia. These findings span peripheral immune markers, especially cytokine abnormalities.Recent FindingsThis review describes recent genetic and immune marker studies and emergent treatment studies.SummaryCollectively, this provides a synthesis and current appraisal of the neuroimmune hypothesis of schizophrenia.
Source: Current Psychiatry Reports - Category: Psychiatry Source Type: research

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[Cariprazine, a new type - dopamine Dā‚ƒ receptor preferring - partial agonist atypical antipsychotic for the treatment of schizophrenia and the primary negative symptoms]. Neuropsychopharmacol Hung. 2019 Sep;21(3):103-118 Authors: Laszlovszky I, Kiss B, Barabassy A, Kapas M, Nemeth G Abstract Dopamine Dā‚‚ receptor partial agonists represent a new generation of atypical antipsychotics. Cariprazine, which has received centralized market authorization from the European Medicines Agency in 2017 for the treatment of adult patients with schizophrenia (including those with predominant negative symptoms of s...
Source: Neuropsychopharmacologia Hungarica - Category: Psychiatry Tags: Neuropsychopharmacol Hung Source Type: research
Publication date: Available online 20 September 2019Source: Neuroscience &Biobehavioral ReviewsAuthor(s): Gerwyn Morris, Basant K. Puri, Adam J. Walker, Michael Maes, Andre F. Carvalho, Ken Walder, Michael BerkAbstractActivated immune-inflammatory, oxidative and nitrosative stress (IO&NS) pathways and consequent mitochondrial aberrations are involved in the pathophysiology of psychiatric disorders including major depression, bipolar disorder and schizophrenia. They offer independent and shared contributions to pathways underpinning medical comorbidities including insulin resistance, metabolic syndrome, obesity and card...
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research
Conclusions. This study identified the unique role of demographic and clinical variables in mental illness stigma among patients with schizophrenia. Nurses should consider these variables when implementing anti-stigma intervention programs. Impact Statement Both clinical and demographic variables are associated with perceived stigma toward mental illness among patients diagnosed with schizophrenia. PMID: 31535959 [PubMed - as supplied by publisher]
Source: Contemporary Nurse - Category: Nursing Tags: Contemp Nurse Source Type: research
Hi, I have been taking medicare patients for a while. lately after a local community center went bankrupt, i decided to take a few patients. One current issue I keep having is that medicare keeps denying coverage for labs like cbc, chem panel, lipids, hemoglobin A1c. The labs (quest/labcorp) don't know what it is either other than we have the wrong codes. I am using the standard codes for bipolar/schizophrenia. F31.x, F20.x etc. Anyone else having this issues/have experience with this?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Psychiatry Source Type: forums
Authors: Kane JM, Correll CU Abstract Acute and long-term objectives must be linked early in the treatment of schizophrenia. Maintenance therapy is pivotal in relapse prevention. Relapses are serious events that alter disease trajectory and are most often related to nonadherence. Patients with schizophrenia have a substantial risk of relapse, especially when they are nonadherent to antipsychotics. Because relapses are accompanied by structural brain changes, worsening symptoms, and increased treatment resistance when medication is resumed, clinicians must monitor nonadherence and offer strategies to avoid or improv...
Source: Journal of Clinical Psychiatry - Category: Psychiatry Tags: J Clin Psychiatry Source Type: research
CONCLUSIONS: The current study highlights that early prevention of periodontal disease in individuals with schizophrenia is crucial. Along with paying more attention to the development of periodontal disease, assessing oral health regularly, helping with oral hygiene, and lowering consumption of sugary drinks and tobacco, emphasis should also be given by physicians to reduce the prescription of antipsychotics to the extent possible under efficacious pharmacotherapy for schizophrenia. PMID: 31526409 [PubMed - as supplied by publisher]
Source: Epidemiology and Psychiatric Sciences - Category: Psychiatry Tags: Epidemiol Psychiatr Sci Source Type: research
ConclusionOur panoramic meta-overview suggests that exercise can be an effective adjunctive treatment for improving symptoms across a broad range of mental disorders.
Source: Sports Medicine - Category: Sports Medicine Source Type: research
This study was aimed at testing explanatory models of negative and positive experiences of caregiving considering the role of the caregiver’s perceptions of difficulties, satisfaction, and coping. A convenience sample of 159 informal caregivers of patients with schizophrenia was used in this study. Different variables were considered: (1) perception of difficulties (Caregiver’s Assessment of Difficulties Index); (2) perception of satisfaction (Caregiver’s Assessment of Satisfaction Index); (3) perception of coping (Caregiver’s Assessment of Managing Index); and (4) the experience of ...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
by Justin D. Rasmussen, Bernard Kakuhikire, Charles Baguma, Scholastic Ashaba, Christine E. Cooper-Vince, Jessica M. Perkins, David R. Bangsberg, Alexander C. Tsai BackgroundMental illness stigma is a fundamental barrier to improving mental health worldwide, but little is known about how to durably reduce it. Understanding of mental illness as a treatable medical condition may influence stigmatizing beliefs, but available evidence to inform this hypothesis has been derived solely from high-income countries. We embedded a randomized survey experiment within a whole-population cohort study in rural southwestern Uganda to ass...
Source: PLoS Medicine - Category: Internal Medicine Authors: Source Type: research
So now, according to the Washington Post, the Trump Administration is “…considering a controversial proposal to study whether mass shootings could be prevented by monitoring mentally ill people for small changes that might foretell violence.”1 As a psychiatrist, I keep wondering how many times the White House will scapegoat those with psychiatric illnesses rather than looking at the scientific data on mass shooters. To understand the problem, consider the case of “Tyler” (a composite of many mass shooter profiles). Tyler is a 19-year-old, single, unemployed high school dropout. He was wo...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Criminal Justice Mental Health and Wellness Stigma Violence and Aggression extreme risk protection order mass shooting Mental Illness red flag law Source Type: blogs
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