A MEG study of the neural substrates of semantic processing in semantic variant primary progressive aphasia.
A MEG study of the neural substrates of semantic processing in semantic variant primary progressive aphasia. Neurocase. 2019 Jul 01;:1-12 Authors: Pineault J, Jolicœur P, Grimault S, Lacombe J, Brambati SM, Bier N, Chayer C, Joubert S Abstract Despite a well-documented pattern of semantic impairment, the patterns of brain activation during semantic processing in semantic variant primary progressive aphasia (svPPA) still remain poorly understood. In the current study, one svPPA patient (EC) and six elderly controls carried out a general-level semantic categorization task while their brain activity was recorded using magnetoencephalography (MEG). Despite similar behavioral performance, EC showed hyperactivation of the left inferior temporal gyrus (ITG) and right anterior temporal lobe (ATL) relative to controls. This suggests that periatrophic regions within the ATL region may support preserved semantic abilities in svPPA. PMID: 31256711 [PubMed - as supplied by publisher]
ConclusionSSRI therapy did not improve disability and QOL in multi-ethnic Asian patients with first-ever stroke undergoing rehabilitation.
A 27-year-old male presented to the emergency department with altered mental status well as aphasia, lethargy, and dizziness that developed over the previous two days. His family denied any recent seizure-like activity, loss of consciousness, nausea, vomiting, or fevers.
We described a case of PACNS initially misdiagnosed as glioblastoma. The patient was a 35 year-old female with right-sided weakness and expressive dysphasia. Brain MRI showed a tumor-like lesion highly suggestive of glioblastoma, therefor surgical removal was done. After a resection and an exhaustive workup, PACNS was ultimately diagnosed. The case illustrates a type of imaging presentation of PACNS that is often misdiagnosed as high-grade glioma. Differentiation between tumor-like PACNS lesions and actual CNS tumors is challenging due to similar MR images. To avoid unnecessary surgical interventions, we summarized previou...
(Medical University of South Carolina) Researchers at the Medical University of South Carolina (MUSC) and elsewhere report in Brain that the left lateral temporal cortex must be intact in stroke patients with aphasia if they are to have their speech entrained. In speech entrainment, stroke survivors practice fluent speech production by following along with another speaker. The efficacy of this experimental approach for certain patients with non-fluent aphasia will be assessed by an MUSC-led multi-site trial.
Conclusion: For the purpose of delirium screening in patients with aphasia, increasing the ICDSC cut-off value to ≥ 5 points enables effective screening. Further studies are necessary to characterize post-stroke delirium.
ConclusionRight-hemispheric symptoms appear to be less clinically conspicuous resulting in a delayed diagnosis of GBM, which might be improved by raising awareness for the corresponding neuropsychological deficits. Whether our findings have prognostic implications needs to be evaluated in future studies.
Abstract How do health and social care professionals deal with undecipherable talk produced by adults with intellectual disabilities (ID)? Some of their practices are familiar from the other-initiated repair canon. But some practices seem designed for, or at least responsive to, the needs of the institutional task at hand, rather than those of difficult-to-understand conversational partners. One such practice is to reduce the likelihood of the person with ID issuing any but the least repair-likely utterances, or indeed having to speak at all. If they do produce a repairable turn, then, as foreshadowed by earlier w...
Conclusions The current results suggest that PWA use gestures to compensate for their verbal limitations under varying communicative constraints. The properties of the communicative task influence the use of different gesture types in people with and without aphasia. Thus, the influence of communicative constraints needs to be considered when assessing PWA's multimodal communicative abilities. PMID: 31710512 [PubMed - as supplied by publisher]