Dengue Virus in Traveler Returning to Japan from the Democratic Republic of the Congo, 2015.

Dengue Virus in Traveler Returning to Japan from the Democratic Republic of the Congo, 2015. Jpn J Infect Dis. 2019 Jun 28;: Authors: Yamamoto SP, Kasamatsu Y, Kanbayashi D, Kaida A, Shirano M, Kubo H, Goto T, Iritani N Abstract Dengue fever (DF) is a mosquito-borne disease and significant global public health problem. Although limited serologic surveys in the literature suggest endemic DF in many parts of Africa, DF cases in Africa are generally underreported due to the lack of diagnostic testing and systematic surveillance, and thus, little is known about the phylogenetic profile of circulating strains. In April 2015, DF was diagnosed in a Japanese national returned from the Democratic Republic of the Congo (DRC). Dengue virus 1 (DENV-1) RNA was detected from the patient's serum sample by real-time reverse transcription PCR. Phylogenetic analysis of the E gene found that the detected DENV-1 strain was classified in genotype V and closely related to that of the 2013 DF epidemic in Angola, which is located directly south of DRC, with 100% nucleotide identity. This is the first report to characterize the circulating DENV strain in DRC, and indicates that the epidemic DENV-1 strain in Angola in 2013 was also circulating in DRC in 2015. PMID: 31257241 [PubMed - as supplied by publisher]
Source: Japanese Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Jpn J Infect Dis Source Type: research

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Publication date: Available online 16 December 2019Source: Antiviral ResearchAuthor(s): Michael W. Gaunt, Duane J. Gubler, John H.-O. Pettersson, Goro Kuno, Annelies Wilder-Smith, Xavier de Lamballerie, Ernest A. Gould, Andrew K. FalconarAbstractSporadic human Zika virus (ZIKV) infections have been recorded in Africa and Asia since the 1950s. Major epidemics occurred only after ZIKV emerged in the Pacific islands and spread to the Americas. Specific biological determinants of the explosive epidemic nature of ZIKV have not been identified. Phylogenetic studies revealed incongruence in ZIKV placement in relation to Aedes-bor...
Source: Antiviral Therapy - Category: Virology Source Type: research
Abstract Sporadic human Zika virus (ZIKV) infections have been recorded in Africa and Asia since the 1950s. Major epidemics occurred only after ZIKV emerged in the Pacific islands and spread to the Americas. Specific biological determinants of the explosive epidemic nature of ZIKV have not been identified. Phylogenetic studies revealed incongruence in ZIKV placement in relation to Aedes-borne dengue viruses (DENV) and Culex-borne flaviviruses. We hypothesized that this incongruence reflects interspecies recombination resulting in ZIKV evasion of cross-protective T-cell immunity. We investigated ZIKV phylogenetic i...
Source: Antiviral Research - Category: Virology Authors: Tags: Antiviral Res Source Type: research
Abstract Flaviviruses are group of single stranded RNA viruses that cause severe endemic infection and epidemics on a global scale. It presents a significant health impact worldwide and the viruses have the potential to emerge and outbreak in a non-endemic geographical region. Effective vaccines for prophylaxis are only available for several flaviviruses such as Yellow Fever virus, Tick-borne Encephalitis Virus, Dengue Virus and Japanese Encephalitis Virus and there is no antiflaviviral agent being marketed. This review discusses the flavivirus genome, replication cycle, epidemiology, clinical presentation and pat...
Source: Virus Research - Category: Virology Authors: Tags: Virus Res Source Type: research
CONCLUSIONS: Children are especially vulnerable to this group of diseases due to characteristics that facilitate the development of the most severe forms. More detailed knowledge of this group of diseases allows the pediatrician to diagnose them earlier, implement the correct treatment, monitor warning signs for the most severe forms, and establish effective preventive measures. PMID: 31605670 [PubMed - as supplied by publisher]
Source: Jornal de Pediatria - Category: Pediatrics Authors: Tags: J Pediatr (Rio J) Source Type: research
The objective of the study was estimate the seroprevalence of ZIKV infection during the pre-epidemic phase in Barranquilla, Colombia, and demonstrate the presence of virus before the Colombian Ministry of Health confirmed the first case. We conducted a descriptive study of the seroprevalence of Zika virus in 390 samples obtained from a blood bank located in Barranquilla, Colombia - a city endemic for dengue, and with a recent history of a Chikungunya disease epidemic. The serum pools were tested using Euroimmun ZIKV ELISA kit. Seroprevalence of Zika virus IgG were: May 2015: 0%, June and July 2015: 2.62% (95% CI = 0.28-12....
Source: An Acad Bras Cienc - Category: Science Authors: Tags: An Acad Bras Cienc Source Type: research
CONCLUSIONS: Seven out of 100 inhabitants of Manaus Metropolitan Region reported dengue in the previous year. Dengue was predominantly observed in women, elderly individuals, White and Asian individuals, and individuals who did not receive endemic agent visits. The setting plays an important role in dengue infections.
Source: Revista da Sociedade Brasileira de Medicina Tropical - Category: Tropical Medicine Source Type: research
Discussion Dengue is an important arboviral infection that affects about 40% of the world population. It is found mainly in topical and subtropical areas of the world mainly in developing countries but it range is spreading including the United States. A review of common arboviruses can be found here. It is a flaviavirus with 4 distinct serotypes named DENV-1 through DENV-4 and is spread by A. aegypti a day biting mosquito. Infection with one serotype confers immunity to that serotype but not the others. It does offer some protection for cross-infection but this only lasts a few months. Incubation period is 3-14 days with ...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Climate change is the greatest health challenge of the 21st century, and threatens all aspects of society, says the WHO in its COP24 Special Report. What could digital health technologies do to support the fight against the climate crisis? How could healthcare processes, facilities, medical devices become more sustainable? As it is humanity’s priority to mitigate the worsening as well as the impact of rising temperatures and extreme weather events, we tried to figure out what role digital health could assume here. We found many options – and even more possibilities for future development. The climate crisis...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Medicine air asthma climate climate catastrophe climate change climate crisis digital digital health efficient Healthcare mosquito optimize resilience solar sustainability technology Source Type: blogs
Abstract Population displacement and other forced movement patterns following natural disasters, armed conflicts or due to socioeconomic reasons contribute to the global emergence of Aedes-borne viral disease epidemics. In particular, dengue epidemiology is critically affected by situations of displacement and forced movement patterns, particularly within and across borders. In this respect, waves of human movements have been a major driver for the changing epidemiology and outbreaks of the disease on local, regional and global scales. Both emerging dengue autochthonous transmission and outbreaks in countries know...
Source: Acta Tropica - Category: Infectious Diseases Authors: Tags: Acta Trop Source Type: research
DiscussionFor decades, it has been commonly accepted that an integrated approach to mosquito control is required. The World Health Organization (WHO) Global Strategic Framework for Integrated Vector Management recommends a range of interventions, in combination, to increase control impact to reduce transmission. This efficacy trial of the first commercial product using the AD approach will be informative in assessing the general utility of AD in reducing not only adult vector densities but, more importantly, reducing the incidence of dengue. The AD technique may complement source reduction and larviciding campaigns by more...
Source: Trials - Category: Research Source Type: clinical trials
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