New unsaturated fatty acid and other chemical constituents from the roots of Cola rostrata K. Schum. (Malvaceae)

Publication date: October 2019Source: Biochemical Systematics and Ecology, Volume 86Author(s): Willifred Dongmo Tékapi Tsopgni, Anatole Guy Blaise Azebaze, Jean Emmanuel Mbosso Teinkela, Bruno Lenta Ndjakou, Fabrice Fekam Bosyom, Bonaventure Ngadjui Tchaleu, Juliette Catherine VardamidesAbstractPhytochemical investigation of the roots of Cola rostrata K. Schum. led to the isolation of a new unsaturated fatty acid, named rostratanic acid (1), together with fourteen known compounds, lignoceric acid, friedelan (7), friedelanone (8), bauerenol (3), lupeol (4), herranone (9), acotatarone A (11), betulinic acid (6), betulin (5), nonanedioc acid (2), arjunolic acid (10) stigmasterol, β−sitosterol, and β−sitosterol-3-O-β-D-glucopyranoside. The structure of the new compound as well as those of the known compounds were established by means of spectroscopic methods: NMR analysis (1H and 13C NMR, 1H–1H–COSY, HSQC and HMBC) and high-resolution mass spectrometry (HR-ESI-MS), and by comparison with previously reported data. Two of those known compounds were modified chemically to afford three new derivatives. All those compounds were tested for their cytotoxic activity against the human cervix carcinoma KB-3-1 cells and their antibacterial activity against Escherichia coli, Salmonella enterica, Pseudomonas aeruginosa and Staphylococcus aureus. Although the crude extract gave weak antibacterial activity, none of the isolated compounds showed antibacterial activity, and, only th...
Source: Biochemical Systematics and Ecology - Category: Biochemistry Source Type: research