Megastigmane and abscisic acid glycosides from the leaves of Laurus nobilis L.

Publication date: October 2019Source: Phytochemistry Letters, Volume 33Author(s): Le Duc Dat, Ngo Viet Duc, Bui Thi Thuy Luyen, Ha Van Oanh, Hyun Jae Jang, Tran Thu Huong, Young Ho Kim, Nguyen Phuong ThaoAbstractTwo new megastigmane glycosides, laurusides E-F (1 and 3) and three known ones (2, 5, and 7), together with a new abscisic acid glycoside, lauruside G (4) and a known one (6), were isolated from a methanolic extract of Laurus nobilis L. leaves using various chromatographic techniques. The structures of these compounds were fully characterized using a combination of spectroscopic techniques including multinuclear and multidimensional NMR and mass spectrometry. All of the isolates were evaluated for their inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW264.7 cells.Graphical abstract

Source: Phytochemistry Letters - July 3, 2019 Category: Chemistry Source Type: research