Relationship between Structural Characteristics and Plant Sources along with Pharmacology Research of Quassinoids.

Relationship between Structural Characteristics and Plant Sources along with Pharmacology Research of Quassinoids. Chem Pharm Bull (Tokyo). 2019;67(7):654-665 Authors: Li Z, Ruan JY, Sun F, Yan JJ, Wang JL, Zhang ZX, Zhang Y, Wang T Abstract Quassinoids, one kind of triterpenoids with multiple bioactivities such as anti-cancer, anti-malarial, anti-oxidative, anti-microbial, anti-diabetic, anti-viral, and anti-inflammatory effects, have drawn much attention in recent years. Between 2004 and 2018, the structural characteristics and plant sources of 190 quassinoids were reported. Herein, the structure-activity relationships (SARs) of quassinoids along with the anti-cancer mechanisms of four representative quassinoids, eurycomanone, bruceine D, dehydrobruceine B, and brusatol are discussed. This review might be useful for further research and development of quassinoids. PMID: 31257321 [PubMed - in process]
Source: Chemical and Pharmaceutical Bulletin - Category: Drugs & Pharmacology Authors: Tags: Chem Pharm Bull (Tokyo) Source Type: research