The Role of the Sodium-taurocholate Co-transporting Polypeptide (NTCP) and Bile Salt Export Pump (BSEP) in Related Liver Disease.

CONCLUSION: NTCP and BSEP are important proteins for transportation and homeostasis maintenance of bile acids. Further research is needed to develop new models for determining the structure-function relationship of bile acid transporters and screening for substrates and inhibitors, as well as to gain more information about the regulatory genetic mechanisms involved in the processes of liver injury.
PMID: 31258056 [PubMed - in process]

Source: Current Drug Metabolism - July 2, 2019 Category: Drugs & Pharmacology Authors: Lu X, Liu L, Shan W, Kong L, Chen N, Lou Y, Zeng S Tags: Curr Drug Metab Source Type: research