Monocytes contribute to DNA sensing through the TBK1 signaling pathway in type 1 diabetes patients.

CONCLUSIONS: Here, we show that there were significant differences in DNA sensing in T1D patients compared to that in controls. We demonstrate that monocytes from T1D patients are able to sense microbial- and self-DNA, leading to proinflammatory cytokine secretion through the adaptor protein STING and the TBK1 kinase.
PMID: 31256920 [PubMed - as supplied by publisher]

Source: Journal of Autoimmunity - June 26, 2019 Category: Allergy & Immunology Authors: Zentsova I, Parackova Z, Kayserova J, Palova-Jelinkova L, Vrabcova P, Volfova N, Sumnik Z, Pruhova S, Petruzelkova L, Sediva A Tags: J Autoimmun Source Type: research