Asperosaponin VI protects against bone destructions in collagen induced arthritis by inhibiting osteoclastogenesis

ConclusionAVI exertes its anti-osteoclastogenic activity both in vitro and in vivo by inhibiting RANKL-induced osteoclast differentiation and function. Thus, our studies demonstrate a potential therapeutic role for AVI in preventing or inhibiting RANKL-mediated osteolytic bone diseases.Graphical abstract
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research