The cancer cell glycocalyx proteoglycan glypican-1 mediates interstitial flow mechanotransduction to enhance cell migration and metastasis.

CONCLUSIONS: Glypican-1 provides the mechanical linkage from HS (the flow sensor) to the SN12L1 cell where mechanotransduction leading to the enhancement of migration (metastasis) occurs. MAPKs downstream of Glypican-1 propagate the signal. The HS, Glypican-1, MAPK signaling axis suggests opportunities for pharmaceutical intervention. PMID: 31256115 [PubMed - as supplied by publisher]
Source: Biorheology - Category: Biochemistry Tags: Biorheology Source Type: research