Unraveling the role of NSAIDs in the link between osteoarthritis and cardiovascular disease via causal mediation analysis – a guide to interpretation

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Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Editorial Source Type: research

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This study explored the role of central sensitization (CS) pain in patients with various rheumatic diseases using the CS inventory (CSI).MethodsA total of 193 patients of mean age 50.72  ± 9.65 years were included; they were divided into four different groups in terms of their rheumatic diseases. Patients with rheumatoid arthritis (RA), spondyloarthropathy (SpA), osteoarthritis (OA), and fibromyalgia syndrome (FMS) were evaluated in tertiary care rheumatology/pain medicine se ttings. Disease duration and activity, the Bath Ankylosing Spondylitis Disease Activity Index, the Disease Activity Score-2...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
Abstract OBJECTIVES: Evaluate the relationship between arthritis diagnosis in those over 50 and exposure to extreme air pollution in utero or infancy (
Source: Environmental Pollution - Category: Environmental Health Authors: Tags: Environ Pollut Source Type: research
Publication date: Available online 22 August 2019Source: Life SciencesAuthor(s): Mehana E. El-Sayed, Khafaga F. Asmaa, El-Blehi S. SamarAbstractExtensive degeneration of articular cartilage (AC) is a primary event in the pathogenesis of osteoarthritis (OA) and other types of joint and bone inflammation. OA results in the loss of joint function, usually accompanied by severe pain, and are the most common type of arthritis, affecting more than 10% of adults. The characteristic signs of OA are progressive cartilage destruction and, eventually, complete loss of chondrocytes. A key enzyme responsible for these degenerative chan...
Source: Life Sciences - Category: Biology Source Type: research
Predicting which patients with hip osteoarthritis are more likely to show disease progression is important for healthcare professionals. Therefore, the aim of this review was to assess which factors are predic...
Source: Arthritis Research and Therapy - Category: Rheumatology Authors: Tags: Review Source Type: research
This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Reply to Letter to the Editor Source Type: research
Authors: Cai S, Ming B, Ye C, Lin S, Hu P, Tang J, Zheng F, Dong L Abstract Rheumatoid arthritis (RA) and osteoarthritis (OA) are common rheumatic disorders that primarily involve joints. The inflammation of the synovium can be observed in both of the two diseases. Synovial fibroblasts (SFs) play an important role in the inflammatory process of the synovium. The functional states of synovial fibroblasts are heterogeneous, and the detailed transition process of their functional states is still unclear. By using transcriptomic data of SFs at a single-cell level, we found a similar transition process for SFs in RA and...
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
Publication date: Available online 19 August 2019Source: World Journal of Acupuncture - MoxibustionAuthor(s): Xiu-feng GU, Fei WANG, Yan-yan ZHANGAbstractObjectiveTo compare the therapeutic effect difference among dog-day moxibustion on herbs, ordinary moxibution and routine western medication in treating knee-joint osteoarthritis of yang deficiency and congealing cold type.MethodsA total of 90 patients with knee-joint osteoarthritis of yang deficiency and congealing cold type were divided into dog-day moxibustion group, ordinary moxibution group and western medication group according to the registration order, and there w...
Source: World Journal of Acupuncture Moxibustion - Category: Complementary Medicine Source Type: research
This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Letter to the Editor Source Type: research
ConclusionPain improved considerably in both arms over 60 months. While ITT analysis revealed no statistically significant differences in TKR use, greater TKR utilization in those receiving APM merits further study.
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Full Length Source Type: research
The objective of this review is to summarize the molecular mechanisms of inflammation and oxidative stress activated by Cd at the bone level, particularly in osteoporosis, RA, and OA. Cadmium can increase bone resorption, affect the activity of osteoclasts and calcium (Ca) absorption, and impair kidney function, which favors the development of osteoporosis. In the case of RA, Cd interferes with the activity of antioxidant proteins, like superoxide dismutase (SOD) and catalase (CAT). It also promotes an inflammatory state, inducing the process of citrullination, which affects the proteins of immune response. On the other ha...
Source: Environmental Toxicology and Pharmacology - Category: Environmental Health Source Type: research
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