Kidney injury in the murine models of hematopoietic stem cell transplantation

Allogenic hematopoietic stem cell transplantation (allo-HSCT) can cause an acute graft-versus-host disease (GVHD) [1]. Acute GVHD is an alloimmune response elicited by donor T-cells against epithelial cells, resulting in tissue injury in different organs of the recipient. Organs commonly targeted by acute GVHD are the skin, liver, and gastrointestinal tract. However, tissue injury in other organs, including kidneys, are frequently detected after allo-HSCT [2]. Acute kidney injury is reported in 50%-73% of patients undergoing allo-HSCT [2].

Source: Biology of Blood and Marrow Transplantation - June 30, 2019 Category: Hematology Authors: Qing Ma, Dan Li, Hernan G. Vasquez, M. James You, Vahid Afshar-Kharghan Source Type: research