Comparison of Neutropenia Associated with Ceftaroline or Ceftriaxone in Patients Receiving at Least 7 Days of Therapy for Severe Infections

The objective was to determine drug and patient factors associated with neutropenia in patients receiving ceftaroline or ceftriaxone for deep ‐seated infections.DesignRetrospective, ratio ‐matched cohort study.SettingFour acute ‐care hospitals within an urban health care system.PatientsA total of 176 hospitalized adults who received definitive ceftaroline (44 patients) or ceftriaxone (132 patients) therapy for at least 7 days between January 2013 and April 2017 for any of the following indications: bone and joint infections (BJI), infective endocarditis (IE), or bloodstream infections (BSI).Measurements and Main ResultsThe primary outcome was development of neutropenia while receiving cephalosporin therapy, defined as an absolute neutrophil count (ANC)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - Category: Drugs & Pharmacology Authors: Tags: Original Research Article Source Type: research

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In this study, we showed the incidence of antimicrobial resistance and the susceptibility patterns among 635 VGS isolates from dental plaque. PMID: 32938847 [PubMed - in process]
Source: Biocontrol Science - Category: Microbiology Tags: Biocontrol Sci Source Type: research
Publication date: Available online 18 September 2020Source: Indian Heart JournalAuthor(s): Abhishek Goyal, Bishav Mohan, Pawan Kumar, Dinesh Gupta, Rohit Tandon, Sonaal Singla, Gurbhej Singh, Bhupinder Singh, Shibba Takkar Chhabra, Naved Aslam, Gurpreet S. Wander
Source: Indian Heart Journal - Category: Cardiology Source Type: research
CONCLUSION: One-third of patients who presented with left-sided endocarditis in routine clinical practice were possible candidates for switching to partial oral treatment. This could have major implications for both the patient's quality of life and healthcare costs. These results offer an interesting perspective for implementation of such a strategy, which should be accompanied by a prospective cost-effectiveness analysis. PMID: 32940869 [PubMed - as supplied by publisher]
Source: Netherlands Heart Journal - Category: Cardiology Authors: Tags: Neth Heart J Source Type: research
Abstract PURPOSE: Prognostic studies derived from samples of patients managed in tertiary hospitals are subject to referral bias. We aimed to characterise this bias using the example of infective endocarditis (IE). METHODS: We analysed data from a French population-based cohort which included 497 patients with IE in 2008. Patients were admitted directly to a tertiary hospital (group T), or admitted to a non-tertiary hospital and referred to a tertiary hospital (group NTT) or not (group NT). We compared patients' characteristics and survival rates and prognostic factors between groups. RESULTS: Compared t...
Source: Annals of Epidemiology - Category: Epidemiology Authors: Tags: Ann Epidemiol Source Type: research
Authors: Kobayashi S, Kakeshita K, Imamura T, Fujioka H, Yamazaki H, Koike T, Kinugawa K Abstract A 54-year-old man was admitted to our institute with a diagnosis of infectious endocarditis with vegetation on the mitral valve and severe regurgitation due to Gemella morbillorum infection together with renal dysfunction, which was eventually diagnosed as infection-related pauci-immune necrotizing crescentic glomerulonephritis. Given the refractoriness to antibiotics, the persistent activity of nephritis, and repeated cerebral hemorrhaging, we prioritized steroid therapy over early surgical mitral valve replacement. F...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
We report a rare case of infective endocarditis complicated by postoperative splenic rupture. A patient underwent urgent mitral valve replacement for infective endocarditis believed to be associated with a recent spinal surgical intervention. The patient developed haemodynamic compromise on the third day postoperatively. Computed tomography showed a splenic rupture as the cause. The patient underwent emergency radiological intervention with coil embolization avoiding the need for a splenectomy and was discharged home.
Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: CASE REPORT Source Type: research
Conclusion The current study demonstrates the incidence of overall, early, and late infective endocarditis following TAVR, ranging from 2 to 8 per 1000 patients. Although it remains a rare event, infective endocarditis following TAVR is associated with high mortality.
Source: Journal of Cardiovascular Medicine - Category: Cardiology Tags: Research articles: Editorial Source Type: research
No abstract available
Source: Journal of Cardiovascular Medicine - Category: Cardiology Tags: Research articles: Editorial Source Type: research
Acute coronary syndrome (ACS) is a rare, but serious complication of infective endocarditis, and diagnosis can be challenging given clinical overlap with other syndromes. A rare cause of ACS in infective endoc...
Source: BMC Cardiovascular Disorders - Category: Cardiology Authors: Tags: Case report Source Type: research
Condition:   Infective Endocarditis Intervention:   Other: Partial oral antimicrobial therapy Sponsor:   Lawson Health Research Institute Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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