Comparison of Neutropenia Associated with Ceftaroline or Ceftriaxone in Patients Receiving at Least 7 Days of Therapy for Severe Infections

The objective was to determine drug and patient factors associated with neutropenia in patients receiving ceftaroline or ceftriaxone for deep ‐seated infections.DesignRetrospective, ratio ‐matched cohort study.SettingFour acute ‐care hospitals within an urban health care system.PatientsA total of 176 hospitalized adults who received definitive ceftaroline (44 patients) or ceftriaxone (132 patients) therapy for at least 7 days between January 2013 and April 2017 for any of the following indications: bone and joint infections (BJI), infective endocarditis (IE), or bloodstream infections (BSI).Measurements and Main ResultsThe primary outcome was development of neutropenia while receiving cephalosporin therapy, defined as an absolute neutrophil count (ANC)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - Category: Drugs & Pharmacology Authors: Tags: Original Research Article Source Type: research

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In this study, C.burnetii was isolated by cell culture method from the heart valve tissue of a Q fever endocarditis case. C.burnetii phase I antigen for the indirect fluorescent antibody test (IFAT) was prepared from the isolated strain. For the isolation and identification of C.burnetii, heart valve tissue of the patient was homogenized and DNA was extracted by tissue extraction kit. C.burnetii DNA in the valve tissue was determined by real-time PCR (Rt-PCR). This C.burnetii DNA positive specimen was inoculated into Vero cells by shell vial centrifugation method. The scraped Vero cells were fixed on the slides after one w...
Source: Mikrobiyoloji Bulteni - Category: Microbiology Tags: Mikrobiyol Bul Source Type: research
AbstractWhile the clinical characteristics and treatment outcomes ofEnterococcus faecalis andE. faecium bacteremia are well known, those ofE. durans bacteremia are still largely unclear. We retrospectively identified 80 adultE. durans bacteremia cases treated at our 2700-bed tertiary care hospital between January 1997 and December 2016. We compared the clinical characteristics and treatment outcomes of the adult patients withE. durans bacteremia (case group) with those ofE. faecalis andE. faecium bacteremia cases (two control groups). The case and control groups were matched for sex, age, and date of onset of bacteremia.E....
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
A 43-year-old man with past history of non IV drug use and Hepatitis C was hospitalized in Internal medicine department due to three days of fatigue and dizziness. Upon admission he was alert, his heart rate was 90 beat per minute, the blood pressure was 91/53mmHg, oxygen saturation was 98% and the body temperature was 37.10c. Physical examination was unremarkable except for cachexia and poor sanitation.
Source: The American Journal of Medicine - Category: General Medicine Authors: Tags: Clinical Communication to the Editor Source Type: research
ConclusionsAortic valve-sparing with the reimplantation technique has been performed for over two decades in our institution, and the results in patients with tricuspid aortic valve (TAV) are excellent in terms of survival and freedom from valve-related adverse outcomes including valve reoperation. These results continue supporting the use of valve sparing root replacement using the reimplantation technique (VSRR) in patients with aortic aneurysm, irrespective of whether they have preoperative AR or not. VSRR is safe, durable, and reproducible, but further follow-up, well into the second decade is still necessary.
Source: Indian Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Publication date: Available online 7 August 2019Source: The Annals of Thoracic SurgeryAuthor(s): Laura Varela Barca, Jose López-Menéndez, Jorge Rodríguez-Roda
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
acute;guez-Roda J PMID: 31400335 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Ann Thorac Surg Source Type: research
Infective endocarditis (IE) is characterized by high rates of in-hospital death, and Staphylococcus aureus infection predicts a worse prognosis. We aimed to assess if admission inflammatory biomarkers (white blood cell – WBC – count, C-reactive protein — CRP, and procalcitonin) are informative on microbiological etiology and short-term outcomes.
Source: International Journal of Cardiology - Category: Cardiology Authors: Source Type: research
Conclusions: The patient's whole-body multi-vessel ischemic events in nearly the same time-phase should have encouraged us to consider the possibility of cardiogenic embolism and thus early examination and treatment, although she was old with a relatively poor response due to early infection and physical discomfort. Clinicians should be aware that aortic valve vegetation induces generalized multi-organ embolism in the setting of infective endocarditis in order to ensure prompt recognition and treatment of this fatal complication.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Source: Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
ConclusionThe “folded valve technique” is a safe and feasible modification of the Melody® valve which provides favourable mid-term results without increased rate of valve related complications.
Source: Archives of Cardiovascular Diseases Supplements - Category: Cardiology Source Type: research
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