Numerical study on the dynamics of primary cilium in pulsatile flows by the immersed boundary-lattice Boltzmann method.

Numerical study on the dynamics of primary cilium in pulsatile flows by the immersed boundary-lattice Boltzmann method.
Biomech Model Mechanobiol. 2019 Jun 29;:
Authors: Cui J, Liu Y, Fu BM
Abstract
An explicit immersed boundary-lattice Boltzmann method is applied to numerically investigate the dynamics of primary cilium in pulsatile blood flows with two-way fluid-structure interaction considered. To well characterize the effect of cilium basal body on cilium dynamics, the cilium base is modeled as a nonlinear rotational spring attached to the cilium's basal end as proposed by Resnick (Biophys J 109:18-25, 2015. https://doi.org/10.1016/j.bpj.2015.05.031 ). After several careful validations, the fluid-cilium interaction system is investigated in detail at various pulsatile flow conditions that are characterized by peak Reynolds numbers ([Formula: see text]) and Womersley numbers ([Formula: see text]). The periodic flapping of primary cilium observed in our simulations is very similar to the in vivo ciliary oscillation captured by O'Connor et al. (Cilia 2:8, 2013. https://doi.org/10.1186/2046-2530-2-8 ). The cilium's dynamics is found to be closely related to the [Formula: see text] and [Formula: see text]. Increase the [Formula: see text] or decrease the [Formula: see text] bring to an increase in the cilium's flapping amplitude, tip angular speed, basal rotation, and maximum tensile stress. It is also demonstrated that by reducing th...

Source: Biomechanics and Modeling in Mechanobiology - June 28, 2019 Category: Biomedical Science Authors: Cui J, Liu Y, Fu BM Tags: Biomech Model Mechanobiol Source Type: research