Type-2 Fuzzy PCA Approach in Extracting Salient Features for Molecular Cancer Diagnostics and Prognostics
Machine learning is becoming a powerful tool for cancer diagnosis and prognosis based on classification using high dimensional molecular data. However, extracting classification features from high-dimensional datasets remains a challenging problem. Principal component analysis (PCA) is a widely used method for dimensionality reduction. However, it is well-known that PCA and most PCA-based feature extraction methods are sensitive to noise, which may affect the accuracy of the subsequent classification. To address this problem, here we have proposed a robust fuzzy principal component analysis (PCA) with interval type-2 (IT-2) fuzzy membership functions for feature extraction. We have tested the performance of three widely used classifiers using the features extracted by proposed approaches and other feature extraction methods - PCA-based feature extraction methods (i.e. conventional PCA and fuzzy PCA), linear discriminant analysis (LDA), and support vector machine recursive feature elimination (SVM-RFE). The proposed feature extraction approaches showed better performance on cancer transcriptome and proteome datasets.
Journal Name: Journal of Perinatal Medicine Issue: Ahead of print
CONCLUSIONS The effect of PL on the SDF-1-CXCR4/CXCR7 axis has become an attractive target for inhibiting angiogenesis in hepatoma cells. Our results provide more evidence for the clinical application of PL as part of traditional Chinese medicine in modern cancer treatment. PMID: 31415486 [PubMed - in process]
In conclusion, this study recognized linc00460 as a new oncogenic lncRNA in OS and suggests that the linc00460/miR-1224-5p/FADS1 axis might be a potential therapeutic target for OS.
Publication date: Available online 17 August 2019Source: Journal of Theoretical BiologyAuthor(s): M. Chowkwale, G.J. Mahler, P. Huang, B.T. MurrayAbstractEndothelial to mesenchymal transformation (EndMT) is a process in which endothelial cells gain a mesenchymal-like phenotype in response to mechanobiological signals that results in the remodeling or repair of underlying tissue. While initially associated with embryonic development, this process has since been shown to occur in adult tissue remodeling including wound healing, fibrosis, and cancer. In an attempt to understand the role of EndMT in cancer progression and meta...
Publication date: 15 November 2019Source: Carbohydrate Polymers, Volume 224Author(s): Mengyao Zhao, Liming Gu, Yun Li, Shumin Chen, Jiangshan You, Liqiang Fan, Yudong Wang, Liming ZhaoAbstractGynecological cancers are the most commonly diagnosed forms of cancer among the female population. Chitooligosaccharides (COS)—hydrolysis products from chitosan—display high bioavailability, high water solubility, and low molecular weight properties. Here, we investigated the influence of COS on 11 gynecological tumor cell types, and subsequently elucidated molecular mechanisms through which the observed inhibition occurre...
Publication date: Available online 17 August 2019Source: PolymerAuthor(s): Sakineh Hajebi, Amin Abdollahi, Hossein Roghani-Mamaqani, Mehdi Salami-KalajahiAbstractSmart drug-delivery systems based on stimuli-responsive polymers are extensively studied because of their advantages in controlled release of anti-cancer drugs in response to induced stimuli. To develop a smart drug-delivery system, silica nanoparticles modified with 3-(trimethoxysilyl) propyl methacrylate (MPS) were used in inverse emulsion polymerization of N,N-dimethylaminoethyl methacrylate with N,N-methylene bisacrylamide in different amounts (MBA: 2, 4, and ...
Publication date: 17 August 2019Source: New Scientist, Volume 243, Issue 3243Author(s):
ConclusionsWe obtained health utility and HRQoL scores of Japanese PC patients stratified by disease progression in detail. Our results will be useful for establishing cost-effectiveness analyses in Japanese PC settings.
Publication date: Available online 17 August 2019Source: European UrologyAuthor(s): Gregory J. Nason, Michael A.S. Jewett, Robert J. Hamilton
Publication date: Available online 16 August 2019Source: European UrologyAuthor(s): Adam W. Glaser