The metalloproteinase ADAM15 is upregulated by shear stress and promotes survival of endothelial cells

Reduced shear stress resulting from disturbed blood flow can impair endothelial integrity and drive the development of vascular inflammatory lesions. Metalloproteinases of the ADAM family have been implicated in the regulation of cell survival and inflammatory responses. Here we investigate the mechanism and function of ADAM15 upregulation in primary flow cultured endothelial cells.Transcriptomic analysis indicated that within the ADAM family ADAM15 mRNA is most prominently upregulated (4-fold) when endothelial cells are exposed to physiologic shear stress.

Source: Journal of Molecular and Cellular Cardiology - June 30, 2019 Category: Cytology Authors: Aaron Babendreyer, Lisa Molls, Indra M. Simons, Daniela Dreymueller, Kristina Biller, Holger Jahr, Bernd Denecke, Reinier A. Boon, Sebastian Bette, Uwe Schnakenberg, Andreas Ludwig Source Type: research