What are the limitations of methods to measure carbon monoxide in biological samples?

ConclusionsAn alternative biomarker is needed, such as determining the total amount of CO in blood. Although further research is required, we recommend that toxicologists consider all sources of error that can alter COHb concentrations, and in more challenging cases, they should use GC –MS methods to confirm the results obtained by spectrophotometry.
Source: Forensic Toxicology - Category: Forensic Medicine Source Type: research