Asbestos Found in Lungs of Half the Thailand Population

Almost 50% of the general population in Thailand will die with at least traces of asbestos in their lungs, based on one recent study. Asbestos fibers were discovered in the lungs of 48.5% of those who were part of a one-year, post-mortem analysis done by the Department of Pathology at Ramathibodi Hospital, Mahidol University in Bangkok. The toxic mineral was found during 97 of the 200 autopsies that were performed at the hospital without regard to occupation, age, sex or cause of death. A two-year-old infant, who died of congenital heart disease, was the youngest to have asbestos identified in the lungs. “The prevalence [of asbestos] is increasing compared to our past study in Thailand,” Dr. Pimpin Incharoen, who co-authored the study, told The Mesothelioma Center at Asbestos.com. “Yes, [the percentage] was surprising.” Asbestos Use in Thailand Remains High A similar study in Thailand in 1985 identified 33% of the general population with asbestos in lung tissue. The percentages in other industrialized countries, using similar post-mortem measurements, varied widely in the past. The most recent comparative study was done in Italy, where asbestos was found in 16.4% percent of those tested. Thailand has been one of the world’s largest importers and users of asbestos for several decades, trailing only Russia, China, India and Kazakhstan in annual consumption. Thailand keeps no standardized, nationwide database to effectively track asbestos-related d...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news

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ConclusionsThese observations suggest that SYD is effective in the enhancement of antioxidant ability via activation of Nrf2 pathway and the up-regulation of Nrf2-downstream phase II enzymes expression. The anti-inflammation and antioxidant action of SYD together contributes to the prevention and treatment of ulcerrelated colorectal cancer.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
In this study, a novel vitamin E succinate-based formulation of Ir (VES-Ir) combined with nanoscaled characteristics and synergistic combination was constructed through esterification. The conjugation makes amphiphilic VES-Ir prodrug self-assemble into nanoparticles with a fine diameter (VES-Ir NPs, 75.4 nm) of spherical morphology. Furthermore, VES-Ir NPs with a 1:1 drug-to-drug ratio was demonstrated to possess respectable physiological stability within 72 h test, while can react to pH/esterase-sensitive drug release in lysosomes internalized into tumor cells, potentially highlighting their alleviating side effects. Comp...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
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Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
Publication date: April 2020Source: Biomedicine &Pharmacotherapy, Volume 124Author(s): Danielle Kamato, Peter J. LittleAbstractThis review will cover the signalling pathways leading to the phosphorylation of the Smad linker region independent of Smad carboxy terminal phosphorylation. Characterising Smad linker region as a signalling pathway in its own right will encourage comprehensive signalling studies to provide solutions for successful discovery and exploitation of drug targets. The review describes Smad transcription factor signalling distinct from Transforming Growth Factor (TGF)-β signalling. Novel signalli...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Conclusion: These results highlight the antiseizure activity of various sesquiterpene compounds from a hexane extract of C. articulatus dried rhizomes and support its use as a traditional treatment for epilepsy.
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
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Source: Expert Opinion on Drug Delivery - Category: Drugs & Pharmacology Authors: Source Type: research
Authors: Hou T, Fan Y, Dan W, Liu B, Wang Z, Zeng J, Li L Abstract Chaperone-mediated autophagy (CMA), a selective form of autophagy, where cellular proteins with KFERQ-like motif are targeted to the lysosome for degradation, is necessary to maintain cellular homeostasis. The role of CMA in neurodegenerative diseases has been extensively studied in the past decades, with defects in the pathway being strongly associated with disease. Recently, accumulating evidence has demonstrated a consistent increase in basal CMA activity in a wide array of cancer cell lines and human tumor biopsies, suggesting a potential link b...
Source: Histology and Histopathology - Category: Cytology Tags: Histol Histopathol Source Type: research
ConclusionsFeature selection methods and classification techniques were applied to mine TCM syndromes. Feature selection improved the performance of the classification models. Of six algorithms, ANN had the highest accuracy of syndrome classification.
Source: European Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
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Source: Reports of Practical Oncology and Radiotherapy - Category: Cancer & Oncology Source Type: research
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Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
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