ESSAY Prostate Cancer Research at the Crossroads

Source: Cold Spring Harbor perspectives in medicine - Category: Research Authors: Tags: Prostate Cancer ESSAY Source Type: research

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Abstract A series of nine new 2,3-disubstituted 4(3H)-quinazolin-4-one derivatives was furnished starting from the 2-propyl-4(3H)-quinazo-line-4-one (2). The reinvestigation of the key starting quinazolinone 2 was performed under microwave irradiation (MW) and solvent-free conditions. Combination of MW and phase-transfer catalysis using tetrabutylammonium benzoate (TBAB) as a novel neutral ionic catalyst was used for carrying out N-alkylation and condensation reactions of compound 2 as a simple, efficient and eco-friendly technique. The structure of the synthesized compounds was elucidated using different spectral...
Source: Acta Pharmaceutica - Category: Drugs & Pharmacology Authors: Tags: Acta Pharm Source Type: research
Abstract The incidence of mortality of prostate cancer (PCa) has been an uptrend in recent years. Our previous study showed that the sex-determining region Y-box 7 (SOX7) was low-expressed and served as a tumor suppressor in PCa cells. Here, we describe the effects of polyphyllin D (PD) on proliferation and cell cycle modifications of PCa cells, and whether SOX7 participates in this process. PC-3 cells were cultured in complete medium containing PD for 12, 24, and 48 h. MTT assay was used to investigate the cytotoxic effects of PD. Cell cycle progression was analyzed using propidium iodide (PI) staining, and prote...
Source: Acta Pharmaceutica - Category: Drugs & Pharmacology Authors: Tags: Acta Pharm Source Type: research
Conclusion: SliceTracker is modular and extensible open source platform for supporting image processing aspects of the tpMRgBx procedure. It has been successfully utilized to support clinical research procedures at our site.
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
Publication date: Available online 20 January 2020Source: Journal of Molecular Graphics and ModellingAuthor(s): Sefer BadayAbstractEnzalutamide is the most recent and potent clinically available drug molecule used to treat castration-resistant metastatic prostate cancer patients. In the presence of certain mutations on the Androgen receptor, enzalutamide fails to function as an antagonist. The molecular mechanism of this resistance has not been understood clearly. Molecular Dynamics (MD) simulations are a powerful tool to investigate such resistance mechanisms. Insights from MD simulations of receptor-ligand complex heavil...
Source: Journal of Molecular Graphics and Modelling - Category: Molecular Biology Source Type: research
A novel method for the synthesis of nonsymmetrical 3,3 ’ -(aryl/alkyl-methylene)bis-2-hydroxy-1,4-naphthoquinones was developed by using the Mannich adduct of naphthoquinone and the reaction with another moiety of 2-hydroxy-1,4-naphthoquinone. This novel method produces for the first time nonsymmetrical 3,3 ’ -(aryl/alkyl-methylene)bis-2-hydroxy-1,4-naphthoquinones. In a preliminary study, these compounds (15c, 15f and 15h) were evaluated regarding their effect over the viability of PC3 metastatic prostate cancer cell using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays at 100 µ...
Source: Journal of the Brazilian Chemical Society - Category: Chemistry Source Type: research
This study revealed that the unexplored co-products in agroindustry may have great therapeutic potential, and therefore should be screened for biologically active compounds.
Source: Journal of the Brazilian Chemical Society - Category: Chemistry Source Type: research
Men with early stage prostate cancer did not show benefits from a vegetable-rich diet.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Prostate Gland Prostate Cancer Vegetables Diet and Nutrition Prostate Specific Antigen Source Type: news
This study aimed to identify the differences in the Raman spectra of serum samples with normal and altered PSA values and correlate these differences by using multivariate techniques (principal component analysis - PCA and partial least squares regression – PLS). A total of 321 spectra were collected from 108 subjects. Two hundred and seventy were obtained from 91 non-altered PSA samples and 51 spectra from 17 samples with altered PSA. Each spectrum acquired was standardized to the area under the curve (1-norm). Discriminating and quantitative models employing PCA and PLS were developed. The PCA analyses showed 85.7%...
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research
AbstractPurpose of ReviewThis review summarizes the prospective clinical evidence regarding local therapy in metastatic prostate cancer.Recent FindingsThe phase 3 STAMPEDE trial showed that prostate radiotherapy confers a survival benefit for newly diagnosed patients with low volume metastatic hormone-sensitive prostate cancer (HSPC). No survival benefit was noted for those with high volume disease. A subsequent meta-analysis combining the data of the STAMPEDE trial with that of the HORRAD trial corroborated these findings. The phase 2 randomized STOMP trial investigated local treatment of metastases in patients with oligo...
Source: Current Oncology Reports - Category: Cancer & Oncology Source Type: research
STAMPEDE is a multi-arm multi-platform randomised controlled trial of treatment for locally advanced, recurrent or hormone-sensitive metastatic prostate cancer, which has energised the UK prostate cancer oncology community. Achieving rapid recruitment, it generated results that have changed systemic therapy practice: docetaxel has been added to lifelong androgen deprivation therapy (ADT) as the standard of care (SoC) in this population, having shown a clinically significant survival advantage [1], and abiraterone is currently being evaluated by the National Institute for Health and Care Excellence (NICE) after showing a co...
Source: Clinical Oncology - Category: Radiology Authors: Tags: Editorial Source Type: research
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