PERSPECTIVES Inner Ear Connexin Channels: Roles in Development and Maintenance of Cochlear Function

Connexin 26 and connexin 30 are the prevailing isoforms in the epithelial and connective tissue gap junction systems of the developing and mature cochlea. The most frequently encountered variants of the genes that encode these connexins, which are transcriptionally coregulated, determine complete loss of protein function and are the predominant cause of prelingual hereditary deafness. Reducing connexin 26 expression by Cre/loxP recombination in the inner ear of adult mice results in a decreased endocochlear potential, increased hearing thresholds, and loss of>90% of outer hair cells, indicating that this connexin is essential for maintenance of cochlear function. In the developing cochlea, connexins are necessary for intercellular calcium signaling activity. Ribbon synapses and basolateral membrane currents fail to mature in inner hair cells of mice that are born with reduced connexin expression, even though hair cells do not express any connexin. In contrast, pannexin 1, an alternative mediator of intercellular signaling, is dispensable for hearing acquisition and auditory function.
Source: Cold Spring Harbor perspectives in medicine - Category: Research Authors: Tags: Function and Dysfunction of the Cochlea PERSPECTIVES Source Type: research

Related Links:

Publication date: Available online 10 October 2020Source: Academic PediatricsAuthor(s): Bonnie Crume
Source: Academic Pediatrics - Category: Pediatrics Source Type: research
Source: European Archives of Oto-Rhino-Laryngology - Category: ENT & OMF Source Type: research
Source: European Archives of Oto-Rhino-Laryngology - Category: ENT & OMF Source Type: research
Condition:   Aphasia Intervention:   Device: Rhythm-based speech therapy app (i.e., Speech Hero) Sponsors:   Ohio State University;   National Institute on Deafness and Other Communication Disorders (NIDCD) Suspended
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
AbstractIntroductionWe aimed to retrospectively analyze the therapeutic outcomes of using glucocorticoid combined with a vasodilator, breviscapine, versus glucocorticoid alone in patients with sudden sensorineural hearing loss (SSNHL) and to explore the impact on different audiometric curves.MethodsData from 154 patients were collected between January 2017 and December 2018. Patients received treatments of either glucocorticoid combined with breviscapine (GC  + Bre) or glucocorticoid alone (GC). These two groups were stratified into low frequencies SSNHL (LF-SSNHL), high frequencies SSNHL (HF-SSNHL), all freq...
Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research
[Nation] Teachers have said government-run online educational programmes following closure of schools due to Covid-19 are inaccessible to children with disabilities, according to a new government report obtained by the Nation.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Condition:   Locked-in Syndrome Intervention:   Device: Summit System Sponsors:   Johns Hopkins University;   UMC Utrecht;   National Institute on Deafness and Other Communication Disorders (NIDCD) Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This article is protected by copyright. All rights reserved. PMID: 33022747 [PubMed - as supplied by publisher]
Source: The Journal of Physiology - Category: Physiology Authors: Tags: J Physiol Source Type: research
[New Frame] The story of friendship brings inclusion and diversity into children's literature, while highlighting the fight to officially recognise sign language in South Africa.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Conclusion Total surgical resection is the treatment of choice in MEAs to minimize the risk for recurrence; this can come with morbidity, mostly sensorineural deafness. Given the very limited literature, long-term follow-up is recommended. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Journal of Neurological Surgery Part B: Skull Base - Category: Neurosurgery Authors: Tags: Original Article Source Type: research
More News: Audiology | Calcium | Deafness | Genetics | Mergers and Aquisitions | Research